Neurotensin receptor: Difference between revisions
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A critical topic in the understanding of GPCRs is the transition from the inactive to active state. This transition is responsible for the [https://en.wikipedia.org/wiki/Signal_transduction transduction] of a signal from the extracellular to the intracellular space. The transition occurs when a ligand, NTS in the case of NTSR1, binds to the receptor causing a [https://en.wikipedia.org/wiki/Conformational_change conformational change] that leads to the activation of the intracellular G protein. Currently, only the structure of the active form of NTSR1 is known, making the transition between the active and inactive states difficult to study.<ref name="SONT"/> | A critical topic in the understanding of GPCRs is the transition from the inactive to active state. This transition is responsible for the [https://en.wikipedia.org/wiki/Signal_transduction transduction] of a signal from the extracellular to the intracellular space. The transition occurs when a ligand, NTS in the case of NTSR1, binds to the receptor causing a [https://en.wikipedia.org/wiki/Conformational_change conformational change] that leads to the activation of the intracellular G protein. Currently, only the structure of the active form of NTSR1 is known, making the transition between the active and inactive states difficult to study.<ref name="SONT"/> | ||
*'''Neurotensin receptor 1''' is involved in the regulation of blood presure, body temperature, weight and response to pain<ref >PMID:31243364</ref> | *'''Neurotensin receptor 1''' is involved in the regulation of blood presure, body temperature, weight and response to pain<ref >PMID:31243364</ref> | ||
*'''Neurotensin receptor 3''' may serve as a scavenger receptor to eliminate neutotensin from the extracellular fluid and trigger its degradation<ref >PMID:11257441</ref> | |||
See also [[Transmembrane (cell surface) receptors]] | See also [[Transmembrane (cell surface) receptors]] | ||