Rho GTPase activating protein: Difference between revisions
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*'''RhoGAP7''' activates the small GTPases RHOA, RHOB, RHOC and CDC42. | *'''RhoGAP7''' activates the small GTPases RHOA, RHOB, RHOC and CDC42. | ||
*'''RhoGAP9''' regulates adhesion of hematopoietic cells to the extracellular matrix. | *'''RhoGAP9''' regulates adhesion of hematopoietic cells to the extracellular matrix. | ||
*'''RhoGAP11''' causes cell-cycle arrest and apoptosis in response to DNA damage. | |||
*'''RhoGAP12''' may be involved in suppressing tumor formation. | |||
*'''RhoGAP21''' involved in cell adhesion, migration, Golgi regulation, cell trafficking and insulin secretion<ref>PMID:29856495</ref>. | |||
*'''RhoGAP21''' involved in cell adhesion, migration, Golgi regulation, cell trafficking and insulin secretion<ref>PMID:29856495</ref>. | |||
*'''RhoGAP35''' involved in cell adhesion, migration and invasion<ref>PMID:35758029</ref>. | |||
== Relevance == | == Relevance == | ||
RhoGAPs are present in altered abundance in a variety of human cancers and may serve as targets for cancer therapy<ref>PMID:16918449</ref>,<ref>PMID:34365932</ref> . | RhoGAPs are present in altered abundance in a variety of human cancers and may serve as targets for cancer therapy<ref>PMID:16918449</ref>,<ref>PMID:34365932</ref>. RhoGAP10 variants may be associated with schizophrenia<ref>PMID:32699248</ref>. | ||
== Structural highlights == | == Structural highlights == | ||