1szi: Difference between revisions

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-[[Image:1szi.gif|left|200px]]
-<!--
+==Crystal Structure of the C-terminus of TIP47==
-The line below this paragraph, containing "STRUCTURE_1szi", creates the "Structure Box" on the page.
+<StructureSection load='1szi' size='340' side='right'caption='[[1szi]], [[Resolution|resolution]] 2.80&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1szi]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SZI OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1SZI FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.8&#8491;</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1szi FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1szi OCA], [https://pdbe.org/1szi PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1szi RCSB], [https://www.ebi.ac.uk/pdbsum/1szi PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1szi ProSAT]</span></td></tr>
-{{STRUCTURE_1szi|  PDB=1szi  |  SCENE=  }}
+</table>
+== Function ==
-'''Crystal Structure of the C-terminus of TIP47'''
+[https://www.uniprot.org/uniprot/PLIN3_MOUSE PLIN3_MOUSE] Required for the transport of mannose 6-phosphate receptors (MPR) from endosomes to the trans-Golgi network (By similarity).
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
-==Overview==
+Check<jmol>
-The perilipin/ADRP/TIP47 (PAT) proteins localize to the surface of intracellular neutral lipid droplets. Perilipin is essential for lipid storage and hormone regulated lipolysis in adipocytes, and perilipin null mice exhibit a dramatic reduction in adipocyte lipid stores. A significant fraction of the approximately 200 amino acid N-terminal region of the PAT proteins consists of 11-mer helical repeats that are also found in apolipoproteins and other lipid-associated proteins. The C-terminal 60% of TIP47, a representative PAT protein, comprises a monomeric and independently folded unit. The crystal structure of the C-terminal portion of TIP47 was determined and refined at 2.8 A resolution. The structure consists of an alpha/beta domain of novel topology and a four-helix bundle resembling the LDL receptor binding domain of apolipoprotein E. The structure suggests an analogy between PAT proteins and apolipoproteins in which helical repeats interact with lipid while the ordered C-terminal region is involved in protein:protein interactions.
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/sz/1szi_consurf.spt"</scriptWhenChecked>
-==About this Structure==
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-SZI is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1SZI OCA].
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
-==Reference==
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1szi ConSurf].
-Structure of a lipid droplet protein; the PAT family member TIP47., Hickenbottom SJ, Kimmel AR, Londos C, Hurley JH, Structure. 2004 Jul;12(7):1199-207. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15242596 15242596]
+<div style="clear:both"></div>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Mus musculus]]
-[[Category: Single protein]]
+[[Category: Hickenbottom SJ]]
-[[Category: Hickenbottom, S J.]]
+[[Category: Hurley JH]]
-[[Category: Hurley, J H.]]
+[[Category: Kimmel AR]]
-[[Category: Kimmel, A R.]]
+[[Category: Londos C]]
-[[Category: Londos, C.]]
-[[Category: 4-helix bundle]]
-[[Category: Alpha/beta domain]]
-[[Category: Pat protein]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 09:18:48 2008''