9dh3: Difference between revisions
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The entry | ==Cryo-EM structure of NLRP3 complex with Compound C== | ||
<StructureSection load='9dh3' size='340' side='right'caption='[[9dh3]], [[Resolution|resolution]] 3.76Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9dh3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9DH3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9DH3 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.76Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1A4L:2-(12-ethyl-9-oxidanylidene-5-thia-1,10,11-triazatricyclo[6.4.0.0^{2,6}]dodeca-2(6),3,7,11-tetraen-10-yl)-~{N}-pyrimidin-4-yl-ethanamide'>A1A4L</scene>, <scene name='pdbligand=ADP:ADENOSINE-5-DIPHOSPHATE'>ADP</scene>, <scene name='pdbligand=CPS:3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE'>CPS</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9dh3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9dh3 OCA], [https://pdbe.org/9dh3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9dh3 RCSB], [https://www.ebi.ac.uk/pdbsum/9dh3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9dh3 ProSAT]</span></td></tr> | |||
</table> | |||
== Disease == | |||
[https://www.uniprot.org/uniprot/NLRP3_HUMAN NLRP3_HUMAN] CINCA syndrome with NLRP3 mutations;Familial cold urticaria;Muckle-Wells syndrome. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/MALE_ECOLI MALE_ECOLI] Involved in the high-affinity maltose membrane transport system MalEFGK. Initial receptor for the active transport of and chemotaxis toward maltooligosaccharides.[https://www.uniprot.org/uniprot/NLRP3_HUMAN NLRP3_HUMAN] As the sensor component of the NLRP3 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP3, PYCARD and CASP1 (and possibly CASP4 and CASP5). Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP3 inflammasome is also required for HMGB1 secretion (PubMed:22801494). The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death. Under resting conditions, NLRP3 is autoinhibited. NLRP3 activation stimuli include extracellular ATP, reactive oxygen species, K(+) efflux, crystals of monosodium urate or cholesterol, beta-amyloid fibers, environmental or industrial particles and nanoparticles, etc. However, it is unclear what constitutes the direct NLRP3 activator. Independently of inflammasome activation, regulates the differentiation of T helper 2 (Th2) cells and has a role in Th2 cell-dependent asthma and tumor growth (By similarity). During Th2 differentiation, required for optimal IRF4 binding to IL4 promoter and for IRF4-dependent IL4 transcription. Binds to the consensus DNA sequence 5'-GRRGGNRGAG-3'. May also participate in the transcription of IL5, IL13, GATA3, CCR3, CCR4 and MAF (By similarity).[UniProtKB:Q8R4B8]<ref>PMID:22801494</ref> <ref>PMID:23305783</ref> | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Abdiaj I]] | |||
[[Category: Adhikary S]] | |||
[[Category: Adriaensen I]] | |||
[[Category: Alcazar J]] | |||
[[Category: Aranzazu GM]] | |||
[[Category: Bassi M]] | |||
[[Category: Brisse E]] | |||
[[Category: Canellas S]] | |||
[[Category: Chaudhuri S]] | |||
[[Category: Chauhan D]] | |||
[[Category: Delgado F]] | |||
[[Category: Dieguez-Vazquez A]] | |||
[[Category: Du Jardin M]] | |||
[[Category: Eastham V]] | |||
[[Category: Edwards MJ]] | |||
[[Category: Finley M]] | |||
[[Category: Grauwen K]] | |||
[[Category: Jacobs T]] | |||
[[Category: Keustermans K]] | |||
[[Category: Kuhn R]] | |||
[[Category: Leenaerts J]] | |||
[[Category: Linares ML]] | |||
[[Category: Llaveria J]] | |||
[[Category: Martin ML]] | |||
[[Category: Martinez C]] | |||
[[Category: Matico R]] | |||
[[Category: Miller R]] | |||
[[Category: Munoz FM]] | |||
[[Category: Muratore EM]] | |||
[[Category: Nooyens A]] | |||
[[Category: Oehlrich D]] | |||
[[Category: Perez LB]] | |||
[[Category: Perrier M]] | |||
[[Category: Pietrak B]] | |||
[[Category: Serre J]] | |||
[[Category: Sharma S]] | |||
[[Category: Somers M]] | |||
[[Category: Suarez J]] | |||
[[Category: Trabanco AA]] | |||
[[Category: Tresadern G]] | |||
[[Category: Van Gool M]] | |||
[[Category: Van Hauwermeiren F]] | |||
[[Category: Van Opdenbosch N]] | |||
[[Category: Van den Bulck D]] | |||
[[Category: Varghese T]] | |||
[[Category: Vega JA]] | |||
[[Category: Youssef SA]] | |||
[[Category: Yu X]] | |||