1z63: Difference between revisions
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z63 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z63 OCA], [https://pdbe.org/1z63 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z63 RCSB], [https://www.ebi.ac.uk/pdbsum/1z63 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z63 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1z63 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1z63 OCA], [https://pdbe.org/1z63 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1z63 RCSB], [https://www.ebi.ac.uk/pdbsum/1z63 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1z63 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z6/1z63_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/z6/1z63_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/ | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
Latest revision as of 03:43, 21 November 2024
Sulfolobus solfataricus SWI2/SNF2 ATPase core in complex with dsDNASulfolobus solfataricus SWI2/SNF2 ATPase core in complex with dsDNA
Structural highlights
Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. Publication Abstract from PubMedSWI2/SNF2 ATPases remodel chromatin or other DNA:protein complexes by a poorly understood mechanism that involves ATP-dependent DNA translocation and generation of superhelical torsion. Crystal structures of a dsDNA-translocating SWI2/SNF2 ATPase core from Sulfolobus solfataricus reveal two helical SWI2/SNF2 specific subdomains, fused to a DExx box helicase-related ATPase core. Fully base paired duplex DNA binds along a central cleft via both minor groove strands, indicating that SWI2/SNF2 ATPases travel along the dsDNA minor groove without strand separation. A structural switch, linking DNA binding and the active site DExx motif, may account for the stimulation of ATPase activity by dsDNA. Our results suggest that torque in remodeling processes is generated by an ATP-driven screw motion of DNA along the active site cleft. The structures also redefine SWI2/SNF2 functional motifs and uncover unexpected structural correlation of mutations in Cockayne and X-linked mental retardation syndromes. X-ray structures of the Sulfolobus solfataricus SWI2/SNF2 ATPase core and its complex with DNA.,Durr H, Korner C, Muller M, Hickmann V, Hopfner KP Cell. 2005 May 6;121(3):363-73. PMID:15882619[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
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