9bk6: Difference between revisions
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==Structure of B10_CYTX binder-complex== | |||
<StructureSection load='9bk6' size='340' side='right'caption='[[9bk6]], [[Resolution|resolution]] 2.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[9bk6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Naja_pallida Naja pallida] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=9BK6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=9BK6 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=9bk6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=9bk6 OCA], [https://pdbe.org/9bk6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=9bk6 RCSB], [https://www.ebi.ac.uk/pdbsum/9bk6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=9bk6 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/3SA1_NAJPA 3SA1_NAJPA] Basic protein that binds to cell membrane and depolarizes cardiomyocytes. This cytotoxin also possesses lytic activity on many other cells, including red blood cells. Interaction with sulfatides in the cell membrane induces pore formation and cell internalization and is responsible for cytotoxicity in cardiomyocytes. It targets the mitochondrial membrane and induces mitochondrial swelling and fragmentation. Inhibits protein kinases C. It binds to the integrin alpha-V/beta-3 with a moderate affinity.[UniProtKB:P01443] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Naja pallida]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Baker D]] | |||
[[Category: Bera AK]] | |||
[[Category: Kang A]] | |||
[[Category: Torres SV]] | |||
Latest revision as of 10:06, 9 October 2024
Structure of B10_CYTX binder-complexStructure of B10_CYTX binder-complex
Structural highlights
Function3SA1_NAJPA Basic protein that binds to cell membrane and depolarizes cardiomyocytes. This cytotoxin also possesses lytic activity on many other cells, including red blood cells. Interaction with sulfatides in the cell membrane induces pore formation and cell internalization and is responsible for cytotoxicity in cardiomyocytes. It targets the mitochondrial membrane and induces mitochondrial swelling and fragmentation. Inhibits protein kinases C. It binds to the integrin alpha-V/beta-3 with a moderate affinity.[UniProtKB:P01443] |
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