Basigin: Difference between revisions
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== Relevance == | == Relevance == | ||
Basigin is involved in regulation of glycolysis and thus in development of malignant tumors and T-cell-mediated immunological disorders<ref>PMID:35844594</ref>. | Basigin is involved in regulation of glycolysis and thus in development of malignant tumors and T-cell-mediated immunological disorders<ref>PMID:35844594</ref>. Hence, basigin has been termed a cancer-associated biomarker and serves as a target for cancer therapy. | ||
== Structural highlights == | == Structural highlights == | ||
The 3D structure of the complex between basigin and the malaria causing ''Plasmodium falciparum'' erythrocyte invading protein reticulocyte binding protein 5 (RH5) shows the N-terminal and C-terminal domains of basigin. RH5 and basigin interact via various hydrogen bonds in both the <scene name='10/1043826/Cv/3'>N-terminal</scene> and C-terminal domains as well as via the 2 domains' linker His102. In addition, the structure shows several hydrophobic interactions between the two proteins<ref>PMID:25132548</ref>. | The 3D structure of the complex between basigin and the malaria causing ''Plasmodium falciparum'' erythrocyte invading protein reticulocyte binding protein 5 (RH5) shows the N-terminal and C-terminal domains of basigin. RH5 and basigin interact via various hydrogen bonds in both the <scene name='10/1043826/Cv/3'>N-terminal</scene> and <scene name='10/1043826/Cv/5'>C-terminal domains</scene> as well as via the 2 domains' linker His102. In addition, the structure shows several hydrophobic interactions between the two proteins<ref>PMID:25132548</ref>. | ||
== Basigin 3D structures == | == Basigin 3D structures == | ||