Cullin-associated NEDD8-disassociated protein: Difference between revisions
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== Function == | == Function == | ||
'''Cullin-associated NEDD8-disassociated protein 1''' (CAND1) is a protein exchange factor that accelerates the rate at which cullin1-Rbx1 equilibrates with multiple F-box proteins and thus controls the SCF ubiquitin ligase repertoire<ref>PMID:23453757</ref>. CAND1 plays a vital role in cullin-RING E3 ligase ubiquitin proteasome systems which control protein degradation. | '''Cullin-associated NEDD8-disassociated protein 1''' (CAND1) is a protein exchange factor that accelerates the rate at which cullin1-Rbx1 equilibrates with multiple F-box proteins and thus controls the SCF ubiquitin ligase repertoire<ref>PMID:23453757</ref>. CAND1 plays a vital role in cullin-RING E3 ligase ubiquitin proteasome systems which control protein degradation. '''Cullin-associated NEDD8-disassociated protein 2''' (CAND2) is linked to mTOR singnaling<ref>PMID:34605609</ref>. | ||
== Disease == | == Disease == | ||
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The 3D structure of the complex between CAND1, cullin1 and RBX as well as other 3D structures of the SCF ubiquitin E3 ligases provide a mechanism of multiprotein complex assembly that averts supply chain problems and rapidly establishes protein degradation pathways needed for cellular regulation<ref>PMID:37028429</ref>. | The 3D structure of the complex between CAND1, cullin1 and RBX as well as other 3D structures of the SCF ubiquitin E3 ligases provide a mechanism of multiprotein complex assembly that averts supply chain problems and rapidly establishes protein degradation pathways needed for cellular regulation<ref>PMID:37028429</ref>. | ||
== 3D structures of cullin-associated NEDD8-disassociated protein | == 3D structures of cullin-associated NEDD8-disassociated protein == | ||
[[CAND1 3D structures]] | [[CAND1 3D structures]] | ||