1tbg: Difference between revisions

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New page: left|200px<br /> <applet load="1tbg" size="450" color="white" frame="true" align="right" spinBox="true" caption="1tbg, resolution 2.1Å" /> '''BETA-GAMMA DIMER OF ...
 
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[[Image:1tbg.gif|left|200px]]<br />
<applet load="1tbg" size="450" color="white" frame="true" align="right" spinBox="true"
caption="1tbg, resolution 2.1&Aring;" />
'''BETA-GAMMA DIMER OF THE HETEROTRIMERIC G-PROTEIN TRANSDUCIN'''<br />


==Overview==
==BETA-GAMMA DIMER OF THE HETEROTRIMERIC G-PROTEIN TRANSDUCIN==
Many signalling cascades use seven-helical transmembrane receptors coupled, to heterotrimeric G proteins (G alpha beta gamma) to convert extracellular, signals into intracellular responses. Upon nucleotide exchange catalysed, by activated receptors, heterotrimers dissociate into GTP-bound G alpha, subunits and G beta gamma dimers, either of which can modulate many, downstream effectors. Here we use multiwavelength anomalous diffraction, data to solve the crystal structure of the beta gamma dimer of the G, protein transducin. The beta-subunit is primarily a seven-bladed, beta-propeller that is partially encircled by an extended gamma-subunit., The beta-propeller, which contains seven structurally similar WD repeats, defines the stereochemistry of the WD repeat and the probable architecture, of all WD-repeat-containing domains. The structure details interactions, between G protein beta- and gamma-subunits and highlights regions, implicated in effector modulation for the conserved family of G protein, beta gamma dimers.
<StructureSection load='1tbg' size='340' side='right'caption='[[1tbg]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[1tbg]] is a 8 chain structure with sequence from [https://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. The October 2004 RCSB PDB [https://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/index.html Molecule of the Month] feature on ''G Proteins''  by David S. Goodsell is [https://dx.doi.org/10.2210/rcsb_pdb/mom_2004_10 10.2210/rcsb_pdb/mom_2004_10]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1TBG OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1TBG FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.1&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1tbg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1tbg OCA], [https://pdbe.org/1tbg PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1tbg RCSB], [https://www.ebi.ac.uk/pdbsum/1tbg PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1tbg ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GBB1_BOVIN GBB1_BOVIN] Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/tb/1tbg_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1tbg ConSurf].
<div style="clear:both"></div>


==About this Structure==
==See Also==
1TBG is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. The following page contains interesting information on the relation of 1TBG with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb58_1.html G Proteins]]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1TBG OCA].
*[[Transducin 3D structures|Transducin 3D structures]]
 
__TOC__
==Reference==
</StructureSection>
Crystal structure of a G-protein beta gamma dimer at 2.1A resolution., Sondek J, Bohm A, Lambright DG, Hamm HE, Sigler PB, Nature. 1996 Jan 25;379(6563):369-74. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=8552196 8552196]
[[Category: Bos taurus]]
[[Category: Bos taurus]]
[[Category: G Proteins]]
[[Category: G Proteins]]
[[Category: Protein complex]]
[[Category: Large Structures]]
[[Category: Bohm, A.]]
[[Category: RCSB PDB Molecule of the Month]]
[[Category: Hamm, H.E.]]
[[Category: Bohm A]]
[[Category: Lambright, D.G.]]
[[Category: Hamm HE]]
[[Category: Sigler, P.B.]]
[[Category: Lambright DG]]
[[Category: Sondek, J.S.]]
[[Category: Sigler PB]]
[[Category: complex (gtp-binding/transducer)]]
[[Category: Sondek JS]]
[[Category: eye]]
[[Category: prenylation]]
[[Category: transducer]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 19:23:12 2007''

Latest revision as of 11:38, 14 February 2024

BETA-GAMMA DIMER OF THE HETEROTRIMERIC G-PROTEIN TRANSDUCINBETA-GAMMA DIMER OF THE HETEROTRIMERIC G-PROTEIN TRANSDUCIN

Structural highlights

1tbg is a 8 chain structure with sequence from Bos taurus. The October 2004 RCSB PDB Molecule of the Month feature on G Proteins by David S. Goodsell is 10.2210/rcsb_pdb/mom_2004_10. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.1Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GBB1_BOVIN Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

1tbg, resolution 2.10Å

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