8yh2: Difference between revisions
New page: '''Unreleased structure''' The entry 8yh2 is ON HOLD Authors: Description: Category: Unreleased Structures |
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==A3R-Gi complex bound to adenosine== | |||
<StructureSection load='8yh2' size='340' side='right'caption='[[8yh2]], [[Resolution|resolution]] 3.27Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8yh2]] is a 5 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens], [https://en.wikipedia.org/wiki/Human_orthopneumovirus Human orthopneumovirus], [https://en.wikipedia.org/wiki/Influenza_A_virus_(A/Victoria/3/1975(H3N2)) Influenza A virus (A/Victoria/3/1975(H3N2))], [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus], [https://en.wikipedia.org/wiki/Ovis_aries Ovis aries] and [https://en.wikipedia.org/wiki/Rattus_rattus Rattus rattus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8YH2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8YH2 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.27Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ADN:ADENOSINE'>ADN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8yh2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8yh2 OCA], [https://pdbe.org/8yh2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8yh2 RCSB], [https://www.ebi.ac.uk/pdbsum/8yh2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8yh2 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/W5QED6_SHEEP W5QED6_SHEEP] Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase.[RuleBase:RU201114][https://www.uniprot.org/uniprot/A0A5P9VSM6_HRSV A0A5P9VSM6_HRSV] [https://www.uniprot.org/uniprot/HEMA_I75A3 HEMA_I75A3] Binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell. This attachment induces virion internalization of about two third of the virus particles through clathrin-dependent endocytosis and about one third through a clathrin- and caveolin-independent pathway. Plays a major role in the determination of host range restriction and virulence. Class I viral fusion protein. Responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. Low pH in endosomes induces an irreversible conformational change in HA2, releasing the fusion hydrophobic peptide. Several trimers are required to form a competent fusion pore. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Human orthopneumovirus]] | |||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Ovis aries]] | |||
[[Category: Rattus rattus]] | |||
[[Category: Nureki O]] | |||
[[Category: Oshima HS]] | |||
[[Category: Shihoya W]] | |||