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| <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f8u OCA], [https://pdbe.org/2f8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f8u RCSB], [https://www.ebi.ac.uk/pdbsum/2f8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f8u ProSAT]</span></td></tr> | | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2f8u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2f8u OCA], [https://pdbe.org/2f8u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2f8u RCSB], [https://www.ebi.ac.uk/pdbsum/2f8u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2f8u ProSAT]</span></td></tr> |
| </table> | | </table> |
| <div style="background-color:#fffaf0;">
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| == Publication Abstract from PubMed ==
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| BCL2 protein functions as an inhibitor of cell apoptosis and has been found to be aberrantly expressed in a wide range of human diseases. A highly GC-rich region upstream of the P1 promoter plays an important role in the transcriptional regulation of BCL2. Here we report the NMR solution structure of the major intramolecular G-quadruplex formed on the G-rich strand of this region in K+ solution. This well-defined mixed parallel/antiparallel-stranded G-quadruplex structure contains three G-tetrads of mixed G-arrangements, which are connected with two lateral loops and one side loop, and four grooves of different widths. The three loops interact with the core G-tetrads in a specific way that defines and stabilizes the overall G-quadruplex structure. The loop conformations are in accord with the experimental mutation and footprinting data. The first 3-nt loop adopts a lateral loop conformation and appears to determine the overall folding of the BCL2 G-quadruplex. The third 1-nt double-chain-reversal loop defines another example of a stable parallel-stranded structural motif using the G3NG3 sequence. Significantly, the distinct major BCL2 promoter G-quadruplex structure suggests that it can be specifically involved in gene modulation and can be an attractive target for pathway-specific drug design.
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| NMR solution structure of the major G-quadruplex structure formed in the human BCL2 promoter region.,Dai J, Chen D, Jones RA, Hurley LH, Yang D Nucleic Acids Res. 2006;34(18):5133-44. Epub 2006 Sep 22. PMID:16998187<ref>PMID:16998187</ref>
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| From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br>
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| </div>
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| <div class="pdbe-citations 2f8u" style="background-color:#fffaf0;"></div>
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| == References ==
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| <references/>
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| __TOC__ | | __TOC__ |
| </StructureSection> | | </StructureSection> |