7gt3: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

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-'''Unreleased structure'''
-The entry 7gt3 is ON HOLD
+==PanDDA Analysis group deposition -- Crystal structure of PTP1B in complex with FMOOA000527a==
+<StructureSection load='7gt3' size='340' side='right'caption='[[7gt3]], [[Resolution|resolution]] 1.59&Aring;' scene=''>
-Authors: Mehlman, T., Ginn, H.M., Keedy, D.A.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7gt3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7GT3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7GT3 FirstGlance]. <br>
-Description: PanDDA Analysis group deposition --Crystal structure of PTP1B in complex with FMOOA000527a
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.59&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=A1ABI:ethyl+(3R,3aS,8bS)-1-acetyl-5-methyl-2,3,3a,8b-tetrahydro-1H-[1]benzofuro[3,2-b]pyrrole-3-carboxylate'>A1ABI</scene>, <scene name='pdbligand=TRS:2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL'>TRS</scene></td></tr>
-[[Category: Mehlman, T]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7gt3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7gt3 OCA], [https://pdbe.org/7gt3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7gt3 RCSB], [https://www.ebi.ac.uk/pdbsum/7gt3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7gt3 ProSAT]</span></td></tr>
-[[Category: Ginn, H.M]]
+</table>
-[[Category: Keedy, D.A]]
+== Function ==
+[https://www.uniprot.org/uniprot/PTN1_HUMAN PTN1_HUMAN] Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion.<ref>PMID:21135139</ref> <ref>PMID:22169477</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Ginn HM]]
+[[Category: Keedy DA]]
+[[Category: Mehlman T]]