Aprepitant: Difference between revisions
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<StructureSection load='' size='340' side='right' caption=' | <StructureSection load='' size='340' side='right' caption='Aprepitant' scene='10/1020314/Cv/1'> | ||
Aprepitant, sold under the brand name Emend among others, is a medication used to prevent chemotherapy-induced nausea and vomiting (CINV) and to prevent postoperative nausea and vomiting (PONV).[ | Aprepitant, sold under the brand name Emend among others, is a medication used to prevent chemotherapy-induced nausea and vomiting (CINV) and to prevent postoperative nausea and vomiting (PONV). It may be used together with ondansetron and dexamethasone.<ref name="a4">[https://www.drugs.com/monograph/aprepitant-fosaprepitant.html "Aprepitant/Fosaprepitant Dimeglumine Monograph for Professionals".] Drugs.com. Archived from the original on 13 August 2020. Retrieved 13 October 2019.</ref> See also [https://en.wikipedia.org/wiki/Aprepitant Aprepitant]. | ||
Aprepitant is classified as an NK1 antagonist because it blocks signals given off by Neurokinin 1 receptors. This, therefore, decreases the likelihood of vomiting in patients. | |||
NK1 is a [[G protein-coupled receptor]] located in the central and peripheral nervous system. This receptor has a dominant ligand known as Substance P (SP). SP is a neuropeptide, composed of 11 amino acids, which sends impulses and messages from the brain. It is found in high concentrations in the vomiting center of the brain, and, when activated, it results in a vomiting reflex. In addition to this it also plays a key part in the transmission of pain impulses from the peripheral receptors to the central nervous system. | |||
Aprepitant has been shown to inhibit both the acute and delayed emesis induced by cytotoxic chemotherapeutic drugs by blocking substance P landing on receptors in the brain's neurons. Positron emission tomography (PET) studies, have demonstrated that aprepitant can cross the blood brain barrier and bind to NK1 receptors in the human brain.<ref name="a9">PMID:15121485</ref> It has also been shown to increase the activity of the [[5-HT3 receptor]] antagonists ondansetron and the [[corticosteroid]] dexamethasone, which are also used to prevent nausea and vomiting caused by chemotherapy.<ref name="a10">PMID:15973669</ref> | |||
<scene name='10/1020314/Cv/2'>Neurokinin 1 receptor in complex with the small molecule antagonist Aprepitant</scene> ([[6hlo]]). | |||
<scene name='10/1020314/Cv/3'>Aprepitant binding site</scene>. | |||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
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