1oqd: Difference between revisions

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OCA

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-[[Image:1oqd.gif|left|200px]]<br />
-<applet load="1oqd" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1oqd, resolution 2.60&Aring;" />
-'''Crystal structure of sTALL-1 and BCMA'''<br />
-==Overview==
+==Crystal structure of sTALL-1 and BCMA==
-The tumour necrosis factor (TNF) ligand TALL-1 and its cognate receptors, BCMA, TACI and BAFF-R, were recently identified as members of the TNF, superfamily, which are essential factors contributing to B-cell, maturation. The functional, soluble fragment of TALL-1 (sTALL-1) forms a, virus-like assembly for its proper function. Here we determine the crystal, structures of sTALL-1 complexed with the extracellular domains of BCMA and, BAFF-R at 2.6 and 2.5 A, respectively. The single cysteine-rich domain of, BCMA and BAFF-R both have saddle-like architectures, which sit on the, horseback-like surface formed by four coil regions on each individual, sTALL-1 monomer. Three novel structural modules, D2, X2 and N, were, revealed from the current structures. Sequence alignments, structural, modelling and mutagenesis revealed that one disulphide bridge in BAFF-R is, critical for determining the binding specificity of the extracellular, domain eBAFF-R to TALL-1 instead of APRIL, a closely related ligand of, TALL-1, which was confirmed by binding experiments in vitro.
+<StructureSection load='1oqd' size='340' side='right'caption='[[1oqd]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1oqd]] is a 18 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OQD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1OQD FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1oqd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oqd OCA], [https://pdbe.org/1oqd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1oqd RCSB], [https://www.ebi.ac.uk/pdbsum/1oqd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1oqd ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/TN13B_HUMAN TN13B_HUMAN] Cytokine that binds to TNFRSF13B/TACI and TNFRSF17/BCMA. TNFSF13/APRIL binds to the same 2 receptors. Together, they form a 2 ligands -2 receptors pathway involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. A third B-cell specific BAFF-receptor (BAFFR/BR3) promotes the survival of mature B-cells and the B-cell response.<ref>PMID:10973284</ref>   Isoform 2 seems to inhibit isoform 1 secretion and bioactivity (By similarity).<ref>PMID:10973284</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/oq/1oqd_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1oqd ConSurf].
+<div style="clear:both"></div>
-==About this Structure==
+==See Also==
-OQD is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1OQD OCA].
+*[[Tumor necrosis factor ligand superfamily 3D structures|Tumor necrosis factor ligand superfamily 3D structures]]
+== References ==
-==Reference==
+<references/>
-Ligand-receptor binding revealed by the TNF family member TALL-1., Liu Y, Hong X, Kappler J, Jiang L, Zhang R, Xu L, Pan CH, Martin WE, Murphy RC, Shu HB, Dai S, Zhang G, Nature. 2003 May 1;423(6935):49-56. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=12721620 12721620]
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Protein complex]]
+[[Category: Large Structures]]
-[[Category: Zhang, G.]]
+[[Category: Zhang G]]
-[[Category: ligand receptor complex]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 18:35:22 2007''