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New page: '''Unreleased structure''' The entry 8wan is ON HOLD Authors: Chen, X., Liu, W., Wang, Q., Wang, X., Ren, Y., Qu, X., Li, W., Xu, Y. Description: Structure of transcribing complex 4 (T... |
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==Structure of transcribing complex 4 (TC4), the initially transcribing complex with Pol II positioned 4nt downstream of TSS.== | |||
<StructureSection load='8wan' size='340' side='right'caption='[[8wan]], [[Resolution|resolution]] 6.07Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8wan]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Amanita_phalloides Amanita phalloides] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8WAN OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8WAN FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.07Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=CSX:S-OXY+CYSTEINE'>CSX</scene>, <scene name='pdbligand=G2L:3-O-METHYOXYETHYL-GUANOSINE-5-MONOPHOSPHATE'>G2L</scene>, <scene name='pdbligand=HYP:4-HYDROXYPROLINE'>HYP</scene>, <scene name='pdbligand=ILX:4,5-DIHYDROXYISOLEUCINE'>ILX</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=SF4:IRON/SULFUR+CLUSTER'>SF4</scene>, <scene name='pdbligand=TRX:6-HYDROXYTRYPTOPHAN'>TRX</scene>, <scene name='pdbligand=W0F:[[(2~{S},3~{R},4~{S},5~{R})-5-(2-azanyl-6-oxidanylidene-3~{H}-purin-9-yl)-3-methoxy-4-oxidanyl-oxolan-2-yl]methoxy-oxidanyl-phosphoryl]+phosphono+hydrogen+phosphate'>W0F</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8wan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8wan OCA], [https://pdbe.org/8wan PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8wan RCSB], [https://www.ebi.ac.uk/pdbsum/8wan PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8wan ProSAT]</span></td></tr> | ||
[[Category: | </table> | ||
[[Category: Chen | == Function == | ||
[[Category: | [https://www.uniprot.org/uniprot/MAT1_HUMAN MAT1_HUMAN] Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.<ref>PMID:10024882</ref> | ||
[[Category: | == References == | ||
[[Category: | <references/> | ||
[[Category: Wang | __TOC__ | ||
[[Category: Wang | </StructureSection> | ||
[[Category: Amanita phalloides]] | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Chen X]] | |||
[[Category: Li W]] | |||
[[Category: Liu W]] | |||
[[Category: Qu X]] | |||
[[Category: Ren Y]] | |||
[[Category: Wang Q]] | |||
[[Category: Wang X]] | |||
[[Category: Xu Y]] | |||
Latest revision as of 11:07, 6 December 2023
Structure of transcribing complex 4 (TC4), the initially transcribing complex with Pol II positioned 4nt downstream of TSS.Structure of transcribing complex 4 (TC4), the initially transcribing complex with Pol II positioned 4nt downstream of TSS.
Structural highlights
FunctionMAT1_HUMAN Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminus domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II.[1] References |
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