Porin: Difference between revisions
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== Function == | == Function == | ||
The function on a porin depends on the size and lining of the channel. | The function on a porin depends on the size and lining of the channel. | ||
*'''OprB''' is a carbohydate-selective porin<ref>PMID:7768797</ref>. | |||
*'''OprF''' protects ''Pseudomonas aeruginosa'' against macrophage clearance<ref>PMID:33432030</ref>. | |||
'''Maltoporin''' (LamB) facilitates the diffusion of maltodextrin across the membrane<ref>PMID:12003940</ref>. | *'''Maltoporin''' (LamB) facilitates the diffusion of maltodextrin across the membrane<ref>PMID:12003940</ref>. | ||
'''Chitoporin''' (Chitp) facilitates the diffusion of chitooligosaccharides across the outer membrane of some bacteria<ref>PMID:23447539</ref>. | *'''Chitoporin''' (Chitp) facilitates the diffusion of chitooligosaccharides across the outer membrane of some bacteria<ref>PMID:23447539</ref>. | ||
'''Voltage-Dependent Anion Channel (VDAC)''' are ion channel Omps found in outer mitochondrial membrane<ref>PMID:16787253</ref>. In ''Pseudomonas aeruginosa'' the porin gene products are named OprD, OprE, OprK, OprP, etc. and OpdC, OpdH, etc. | *'''Voltage-Dependent Anion Channel (VDAC)''' are ion channel Omps found in outer mitochondrial membrane<ref>PMID:16787253</ref>. In ''Pseudomonas aeruginosa'' the porin gene products are named OprD, OprE, OprK, OprP, etc. and OpdC, OpdH, etc. | ||
For discussion of specific porins, see<br /> | For discussion of specific porins, see<br /> | ||
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The channels have wide openings on either side with a tighter bottleneck in the middle, as illustrated in the interactive view <scene name='99/995028/Pacupp/2'>visualizing channels</scene> with pseudoatoms. In an alternative visualization, channels are shown as <scene name='41/411405/Channels/3'>surfaces</scene>, slabbed on both sides of the bottleneck for better visibility. | The channels have wide openings on either side with a tighter bottleneck in the middle, as illustrated in the interactive view <scene name='99/995028/Pacupp/2'>visualizing channels</scene> with pseudoatoms. In an alternative visualization, channels are shown as <scene name='41/411405/Channels/3'>surfaces</scene>, slabbed on both sides of the bottleneck for better visibility. | ||
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Finally, the animation below shows a view perpendicular to the membrane, slicing through different layers of the porin structure with the solvent accessible surface shown in tan. The channels appear narrower in this animation than in the interactive scene because the animation shows the solvent accessible surface while the interactive view shows the molecular surface. | Finally, the animation below shows a view perpendicular to the membrane, slicing through different layers of the porin structure with the solvent accessible surface shown in tan. The channels appear narrower in this animation than in the interactive scene because the animation shows the solvent accessible surface while the interactive view shows the molecular surface. | ||
[[Image:Porin | [[Image:Porin tunnels sliced.gif]] | ||
== 3D structures of Porin == | == 3D structures of Porin == | ||