8q15: Difference between revisions
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==CryoEM structure of canonical rice nucleosome core particle== | |||
<StructureSection load='8q15' size='340' side='right'caption='[[8q15]], [[Resolution|resolution]] 3.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8q15]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryza Oryza] and [https://en.wikipedia.org/wiki/Synthetic_construct Synthetic construct]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8Q15 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8Q15 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6Å</td></tr> | |||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8q15 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8q15 OCA], [https://pdbe.org/8q15 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8q15 RCSB], [https://www.ebi.ac.uk/pdbsum/8q15 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8q15 ProSAT]</span></td></tr> | ||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/H2A2_ORYSI H2A2_ORYSI] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Oryza]] | |||
[[Category: Synthetic construct]] | |||
[[Category: Berger F]] | |||
[[Category: Gireesh A]] | |||
[[Category: Gut F]] | |||
[[Category: Hari Sundar G V]] | |||
[[Category: Jeyaprakash AA]] | |||
[[Category: Jha S]] | |||
[[Category: Raju S]] | |||
[[Category: Shivaprasad PV]] | |||
[[Category: Sotelo-Parrilla P]] | |||
[[Category: Vinothkumar KR]] | |||
Latest revision as of 09:21, 5 February 2025
CryoEM structure of canonical rice nucleosome core particleCryoEM structure of canonical rice nucleosome core particle
Structural highlights
FunctionH2A2_ORYSI Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. |
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