Testosterone: Difference between revisions
No edit summary |
No edit summary |
||
| Line 1: | Line 1: | ||
<StructureSection load='' size='340' side='right' caption='Caption for this structure' scene='98/980335/Cv/1'> | <StructureSection load='' size='340' side='right' caption='Caption for this structure' scene='98/980335/Cv/1'> | ||
Testosterone is the primary male sex hormone and anabolic steroid in males.<ref name="a3">[https://www.mayoclinic.org/healthy-lifestyle/fitness/in-depth/performance-enhancing-drugs/art-20046134|"Understanding the risks of performance-enhancing drugs".] Mayo Clinic. Retrieved December 30, 2019.</ref> In humans, testosterone plays a key role in the development of male reproductive tissues such as testes and prostate, as well as promoting secondary sexual characteristics such as increased muscle and bone mass, and the growth of body hair. It is associated with increased sex drive, the inclination to impress partners and other courting behaviors.<ref name="a4">PMID:3549275</ref> See also [https://en.wikipedia.org/wiki/Testosterone| Testosterone]. | Testosterone is the primary male sex hormone and anabolic steroid in males.<ref name="a3">[https://www.mayoclinic.org/healthy-lifestyle/fitness/in-depth/performance-enhancing-drugs/art-20046134|"Understanding the risks of performance-enhancing drugs".] Mayo Clinic. Retrieved December 30, 2019.</ref> In humans, testosterone plays a key role in the development of male reproductive tissues such as testes and prostate, as well as promoting secondary sexual characteristics such as increased muscle and bone mass, and the growth of body hair. It is associated with increased sex drive, the inclination to impress partners and other courting behaviors.<ref name="a4">PMID:3549275</ref> See also [https://en.wikipedia.org/wiki/Testosterone| Testosterone]. | ||
Testosterone is a steroid from the androstane class. It exerts its action through binding to and activation of the [[androgen receptor]]. Ligand binding domain (LBD) containing an <scene name='54/543362/Cv/3'>active site</scene> which binds intramolecularly the N-terminal FXXFL motif or coactivators with the same motif.<ref>PMID:18805694</ref> Water molecules are shown as red spheres. <scene name='89/895670/Cv/6'>Human androgen receptor bound to testosterone</scene> ([[2ylo]]). | |||
</StructureSection> | </StructureSection> | ||
== References == | == References == | ||
<references/> | <references/> | ||