1lfa: Difference between revisions

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1lfa.gif|left|200px]]<br />
-<applet load="1lfa" size="450" color="white" frame="true" align="right" spinBox="true"
-caption="1lfa, resolution 1.8&Aring;" />
-'''CD11A I-DOMAIN WITH BOUND MN++'''<br />
-==Overview==
+==CD11A I-DOMAIN WITH BOUND MN++==
-We report the 1.8-A crystal structure of the CD11a I-domain with bound, manganese ion. The CD11a I-domain contains binding sites for intercellular, adhesion molecules 1 and 3 and can exist in both low- and high-affinity, states. The metal-bound form reported here is likely to represent a, high-affinity state. The CD11a I-domain structure reveals a strained, hydrophobic ridge adjacent to the bound metal ion that may serve as a, ligand-binding surface and is likely to rearrange in the absence of bound, metal ion. The CD11a I-domain is homologous to domains found in von, Willebrand factor, and mapping of mutations found in types 2a and 2b von, Willebrand disease onto this structure allows consideration of the, molecular basis of these forms of the disease.
+<StructureSection load='1lfa' size='340' side='right'caption='[[1lfa]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1lfa]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LFA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LFA FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=MN:MANGANESE+(II)+ION'>MN</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lfa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lfa OCA], [https://pdbe.org/1lfa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lfa RCSB], [https://www.ebi.ac.uk/pdbsum/1lfa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lfa ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/ITAL_HUMAN ITAL_HUMAN] Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4. It is involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/lf/1lfa_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1lfa ConSurf].
+<div style="clear:both"></div>
-==About this Structure==
+==See Also==
-LFA is a [http://en.wikipedia.org/wiki/Single_protein Single protein] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] with MN and CL as [http://en.wikipedia.org/wiki/ligands ligands]. Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=1LFA OCA].
+*[[Art:Molecular Sculpture|Art:Molecular Sculpture]]
+*[[Hydrogen in macromolecular models|Hydrogen in macromolecular models]]
-==Reference==
+*[[Integrin 3D structures|Integrin 3D structures]]
-Crystal structure of the I-domain from the CD11a/CD18 (LFA-1, alpha L beta 2) integrin., Qu A, Leahy DJ, Proc Natl Acad Sci U S A. 1995 Oct 24;92(22):10277-81. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=7479767 7479767]
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Leahy, D.J.]]
+[[Category: Leahy DJ]]
-[[Category: Qu, A.]]
+[[Category: Qu A]]
-[[Category: CL]]
-[[Category: MN]]
-[[Category: cell adhesion]]
-''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Mon Nov 12 17:59:39 2007''