5ew4: Difference between revisions

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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ew4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ew4 OCA], [https://pdbe.org/5ew4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ew4 RCSB], [https://www.ebi.ac.uk/pdbsum/5ew4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ew4 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ew4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ew4 OCA], [https://pdbe.org/5ew4 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ew4 RCSB], [https://www.ebi.ac.uk/pdbsum/5ew4 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ew4 ProSAT]</span></td></tr>
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Expansion of a GGGGCC/CCCCGG repeat sequence in the first intron of the C9ORF72 gene is a leading cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). In this combined disorder, called c9FTD/ALS, the expansion is bidirectionally transcribed into sense and antisense repeat RNA associated with disease. To better understand the role of C9ORF72 repeat RNA in molecular disease pathology, we determined crystal structures of a [(CCCCGG)3(CCCC)] model antisense repeat RNA to 1.47 A resolution. The RNA structure was an A-form-like double helix composed of repeating and regularly spaced tandem C:C mismatch pairs that perturbed helical geometry and surface charge. Solution studies revealed a preference for A-form-like helical conformations as the repeat number increased. Results provide a structural starting point for rationalizing the contribution of repeat RNA to c9FTD/ALS molecular disease mechanisms and for developing molecules to target C9ORF72 repeat RNA as potential therapeutics.
Pathogenic C9ORF72 Antisense Repeat RNA Forms a Double Helix with Tandem C:C Mismatches.,Dodd DW, Tomchick DR, Corey DR, Gagnon KT Biochemistry. 2016 Feb 22. PMID:26878348<ref>PMID:26878348</ref>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
<div class="pdbe-citations 5ew4" style="background-color:#fffaf0;"></div>
== References ==
<references/>
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</StructureSection>
</StructureSection>

Latest revision as of 15:30, 6 March 2024

Crystal structure of C9ORF72 Antisense CCCCGG repeat RNA associated with Lou Gehrig's disease and frontotemporal dementia, crystallized with Sr2+Crystal structure of C9ORF72 Antisense CCCCGG repeat RNA associated with Lou Gehrig's disease and frontotemporal dementia, crystallized with Sr2+

Structural highlights

5ew4 is a 2 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.47Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

5ew4, resolution 1.47Å

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