8ja5: Difference between revisions

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'''Unreleased structure'''


The entry 8ja5 is ON HOLD  until Paper Publication
==Crystal structure of Nipah Virus attachment (G) glycoprotein in complex with neutralizing antibody 14F8==
 
<StructureSection load='8ja5' size='340' side='right'caption='[[8ja5]], [[Resolution|resolution]] 2.79&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8ja5]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Henipavirus_nipahense Henipavirus nipahense] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8JA5 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8JA5 FirstGlance]. <br>
Description:  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.79&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=MAN:ALPHA-D-MANNOSE'>MAN</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ja5 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ja5 OCA], [https://pdbe.org/8ja5 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ja5 RCSB], [https://www.ebi.ac.uk/pdbsum/8ja5 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ja5 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/GLYCP_NIPAV GLYCP_NIPAV] Interacts with host ephrinB2/EFNB2 or ephrin B3/EFNB3 to provide virion attachment to target cell. This attachment induces virion internalization predominantly through clathrin-mediated endocytosis.<ref>PMID:17470910</ref> <ref>PMID:15961384</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Henipavirus nipahense]]
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Chen W]]
[[Category: Huang XY]]
[[Category: Li YH]]
[[Category: Xu JJ]]

Latest revision as of 11:28, 9 May 2024

Crystal structure of Nipah Virus attachment (G) glycoprotein in complex with neutralizing antibody 14F8Crystal structure of Nipah Virus attachment (G) glycoprotein in complex with neutralizing antibody 14F8

Structural highlights

8ja5 is a 6 chain structure with sequence from Henipavirus nipahense and Mus musculus. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.79Å
Ligands:, , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

GLYCP_NIPAV Interacts with host ephrinB2/EFNB2 or ephrin B3/EFNB3 to provide virion attachment to target cell. This attachment induces virion internalization predominantly through clathrin-mediated endocytosis.[1] [2]

References

  1. ↑ Diederich S, Maisner A. Molecular characteristics of the Nipah virus glycoproteins. Ann N Y Acad Sci. 2007 Apr;1102:39-50. PMID:17470910 doi:http://dx.doi.org/10.1196/annals.1408.003
  2. ↑ Diederich S, Moll M, Klenk HD, Maisner A. The nipah virus fusion protein is cleaved within the endosomal compartment. J Biol Chem. 2005 Aug 19;280(33):29899-903. Epub 2005 Jun 16. PMID:15961384 doi:http://dx.doi.org/10.1074/jbc.M504598200

8ja5, resolution 2.79Å

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OCA
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