1la2: Difference between revisions

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-[[Image:1la2.gif|left|200px]]
-<!--
+==Structural analysis of Saccharomyces cerevisiae myo-inositol phosphate synthase==
-The line below this paragraph, containing "STRUCTURE_1la2", creates the "Structure Box" on the page.
+<StructureSection load='1la2' size='340' side='right'caption='[[1la2]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1la2]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LA2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LA2 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
--->
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene></td></tr>
-{{STRUCTURE_1la2|  PDB=1la2  |  SCENE=  }}
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1la2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1la2 OCA], [https://pdbe.org/1la2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1la2 RCSB], [https://www.ebi.ac.uk/pdbsum/1la2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1la2 ProSAT], [https://www.topsan.org/Proteins/NYSGXRC/1la2 TOPSAN]</span></td></tr>
+</table>
-'''Structural analysis of Saccharomyces cerevisiae myo-inositol phosphate synthase'''
+== Function ==
+[https://www.uniprot.org/uniprot/INO1_YEAST INO1_YEAST]
+== Evolutionary Conservation ==
-==Overview==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/la/1la2_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview03.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1la2 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
 The New York Structural Genomics Research Consortium has targeted highly conserved but uncharacterized enzyme families for structure determination. As part of this effort, the 2.65-A crystal structure has been determined for Saccharomyces cerevisiae myo-inositol 1-phosphate synthase (MIP), an essential enzyme that catalyzes critical steps in inositol biosynthesis. The structure determination of four independent monomers in the asymmetric unit (240 kDa) reveals atomic details and residue composition for the partially closed NAD-containing active sites in apo-configuration. The structure further reveals extensive interactions involved in tetrameric assembly of the enzyme complex.
-==About this Structure==
+Structural analysis of Saccharomyces cerevisiae myo-inositol phosphate synthase.,Kniewel R, Buglino JA, Shen V, Chadha T, Beckwith A, Lima CD J Struct Funct Genomics. 2002;2(3):129-34. PMID:12836703<ref>PMID:12836703</ref>
-LA2 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LA2 OCA].
-==Reference==
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-Structural analysis of Saccharomyces cerevisiae myo-inositol phosphate synthase., Kniewel R, Buglino JA, Shen V, Chadha T, Beckwith A, Lima CD, J Struct Funct Genomics. 2002;2(3):129-34. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12836703 12836703]
+</div>
-[[Category: Inositol-3-phosphate synthase]]
+<div class="pdbe-citations 1la2" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Saccharomyces cerevisiae]]
-[[Category: Single protein]]
+[[Category: Beckwith A]]
-[[Category: Beckwith, A.]]
+[[Category: Buglino JA]]
-[[Category: Buglino, J A.]]
+[[Category: Burley SK]]
-[[Category: Burley, S K.]]
+[[Category: Chadna T]]
-[[Category: Chadna, T.]]
+[[Category: Kniewel R]]
-[[Category: Kniewel, R.]]
+[[Category: Lima CD]]
-[[Category: Lima, C D.]]
+[[Category: Shen V]]
-[[Category: NYSGXRC, New York Structural GenomiX Research Consortium.]]
-[[Category: Shen, V.]]
-[[Category: Ino1]]
-[[Category: Inositol]]
-[[Category: Metabolism]]
-[[Category: New york structural genomix research consortium]]
-[[Category: Nysgxrc]]
-[[Category: Protein structure initiative]]
-[[Category: Psi]]
-[[Category: Structural genomic]]
-[[Category: Yeast]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 23:42:51 2008''