6d8s: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[6d8s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesobuthus_tamulus Mesobuthus tamulus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D8S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6D8S FirstGlance]. <br> | <table><tr><td colspan='2'>[[6d8s]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mesobuthus_tamulus Mesobuthus tamulus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=6D8S OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=6D8S FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6d8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d8s OCA], [https://pdbe.org/6d8s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6d8s RCSB], [https://www.ebi.ac.uk/pdbsum/6d8s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6d8s ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR, 20 models</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=6d8s FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=6d8s OCA], [https://pdbe.org/6d8s PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=6d8s RCSB], [https://www.ebi.ac.uk/pdbsum/6d8s PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=6d8s ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | == Function == | ||
Latest revision as of 10:53, 17 October 2024
NMR solution structure of tamapin, mutant K27ENMR solution structure of tamapin, mutant K27E
Structural highlights
FunctionKAX54_HOTTA Blocks small conductance calcium-activated potassium channels (PubMed:12239213). Shows activity on KCa2.2/KCNN2 (IC(50)=0.0243 nM), KCa2.3/KCNN3 (IC(50)=1.7 nM), and KCa2.1/KCNN1 (IC(50)=42 nM) (PubMed:12239213). Induces cell death when tested on Jurkat E6-1 and human mammary breast cancer MDA-MB-231 which constituvely express KCa2.2/KCNN2, but not on human peripheral blood lymphocytes (which do not express KCa2.2/KCNN2) (PubMed:24821061).[1] See AlsoReferences
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