8p9h: Difference between revisions
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New page: '''Unreleased structure''' The entry 8p9h is ON HOLD Authors: Balourdas, D.I., Bauer, N., Knapp, S., Joerger, A.C., Structural Genomics Consortium (SGC) Description: Crystal structure ... |
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==Crystal structure of the first bromodomain of human BRD4 in complex with the dual BET/HDAC inhibitor NB437== | |||
<StructureSection load='8p9h' size='340' side='right'caption='[[8p9h]], [[Resolution|resolution]] 1.19Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8p9h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8P9H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8P9H FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.19Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=X9C:~{N}-(2-aminophenyl)-2-(6-methyl-7-oxidanylidene-1~{H}-pyrrolo[2,3-c]pyridin-4-yl)quinoline-6-carboxamide'>X9C</scene></td></tr> | ||
[[Category: | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8p9h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8p9h OCA], [https://pdbe.org/8p9h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8p9h RCSB], [https://www.ebi.ac.uk/pdbsum/8p9h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8p9h ProSAT]</span></td></tr> | ||
[[Category: Balourdas | </table> | ||
[[Category: | == Disease == | ||
[[Category: | [https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.<ref>PMID:12543779</ref> <ref>PMID:11733348</ref> | ||
[[Category: | == Function == | ||
[https://www.uniprot.org/uniprot/BRD4_HUMAN BRD4_HUMAN] Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). | |||
== References == | |||
<references/> | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Balourdas DI]] | |||
[[Category: Bauer N]] | |||
[[Category: Joerger AC]] | |||
[[Category: Knapp S]] | |||
Latest revision as of 08:48, 5 July 2023
Crystal structure of the first bromodomain of human BRD4 in complex with the dual BET/HDAC inhibitor NB437Crystal structure of the first bromodomain of human BRD4 in complex with the dual BET/HDAC inhibitor NB437
Structural highlights
DiseaseBRD4_HUMAN Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.[1] [2] FunctionBRD4_HUMAN Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). References
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