4zw1: Difference between revisions
Jump to navigation
Jump to search
No edit summary |
No edit summary |
||
| Line 4: | Line 4: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4zw1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZW1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZW1 FirstGlance]. <br> | <table><tr><td colspan='2'>[[4zw1]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4ZW1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4ZW1 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4V1:2-(4-HYDROXY-3,5-DIMETHYLPHENYL)-7-METHYL-5,6,7,8-TETRAHYDROPYRIDO[4,3 4,5]THIENO[2,3-D]PYRIMIDIN-4(3H)-ONE'>4V1</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.75Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4V1:2-(4-HYDROXY-3,5-DIMETHYLPHENYL)-7-METHYL-5,6,7,8-TETRAHYDROPYRIDO[4,3 4,5]THIENO[2,3-D]PYRIMIDIN-4(3H)-ONE'>4V1</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zw1 OCA], [https://pdbe.org/4zw1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zw1 RCSB], [https://www.ebi.ac.uk/pdbsum/4zw1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zw1 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4zw1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4zw1 OCA], [https://pdbe.org/4zw1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4zw1 RCSB], [https://www.ebi.ac.uk/pdbsum/4zw1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4zw1 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
Latest revision as of 12:05, 20 March 2024
Crystal structure of hBRD4 in complex with BL-BI06 reveals a novel synthesized inhibitor that induces Beclin1-independent/ATG5-dependent autophagic cell death in breast cancerCrystal structure of hBRD4 in complex with BL-BI06 reveals a novel synthesized inhibitor that induces Beclin1-independent/ATG5-dependent autophagic cell death in breast cancer
Structural highlights
DiseaseBRD4_HUMAN Note=A chromosomal aberration involving BRD4 is found in a rare, aggressive, and lethal carcinoma arising in midline organs of young people. Translocation t(15;19)(q14;p13) with NUT which produces a BRD4-NUT fusion protein.[1] [2] FunctionBRD4_HUMAN Plays a role in a process governing chromosomal dynamics during mitosis (By similarity). See AlsoReferences
|
| ||||||||||||||||||