8srm: Difference between revisions
New page: '''Unreleased structure''' The entry 8srm is ON HOLD Authors: Chen, M., Hurley, J.H. Description: Protein kinase complex Category: Unreleased Structures Category: Hurley, J.H [... |
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==Structure of human ULK1 complex core (2:2:2 stoichiometry) of the ATG13(450-517) mutant== | |||
<StructureSection load='8srm' size='340' side='right'caption='[[8srm]], [[Resolution|resolution]] 4.46Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8srm]] is a 6 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8SRM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8SRM FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.46Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8srm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8srm OCA], [https://pdbe.org/8srm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8srm RCSB], [https://www.ebi.ac.uk/pdbsum/8srm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8srm ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ULK1_HUMAN ULK1_HUMAN] Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3-kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK and also acts as a regulator of AMPK by mediating phosphorylation of AMPK subunits PRKAA1, PRKAB2 and PRKAG1, leading to negatively regulate AMPK activity. May phosphorylate ATG13/KIAA0652 and RPTOR; however such data need additional evidences. Plays a role early in neuronal differentiation and is required for granule cell axon formation.<ref>PMID:18936157</ref> <ref>PMID:21460634</ref> <ref>PMID:21795849</ref> | |||
==See Also== | |||
*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: | __TOC__ | ||
[[Category: | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Chen M]] | |||
[[Category: Hurley JH]] | |||