8c9d: Difference between revisions

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-'''Unreleased structure'''
-The entry 8c9d is ON HOLD  until Paper Publication
+==Priestia megaterium W130Q mutant of type 2 isoleucyl-tRNA synthetase complexed with an isoleucyl-adenylate analogue==
+<StructureSection load='8c9d' size='340' side='right'caption='[[8c9d]], [[Resolution|resolution]] 2.30&Aring;' scene=''>
-Authors: Brkic, A., Leibundgut, M., Jablonska, J., Zanki, V., Car, Z., Petrovic Perokovic, V., Ban, N., Gruic-Sovulj, I.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8c9d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Priestia_megaterium Priestia megaterium]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8C9D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8C9D FirstGlance]. <br>
-Description: Priestia megaterium W130Q mutant of type 2 isoleucyl-tRNA synthetase complexed with an isoleucyl-adenylate analogue
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.3&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ILA:N-[ISOLEUCINYL]-N-[ADENOSYL]-DIAMINOSUFONE'>ILA</scene>, <scene name='pdbligand=TAR:D(-)-TARTARIC+ACID'>TAR</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Leibundgut, M]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8c9d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8c9d OCA], [https://pdbe.org/8c9d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8c9d RCSB], [https://www.ebi.ac.uk/pdbsum/8c9d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8c9d ProSAT]</span></td></tr>
-[[Category: Petrovic Perokovic, V]]
+</table>
-[[Category: Gruic-Sovulj, I]]
+== Function ==
-[[Category: Ban, N]]
+[https://www.uniprot.org/uniprot/A0A0B6AVD3_PRIM2 A0A0B6AVD3_PRIM2] Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).[ARBA:ARBA00025217][HAMAP-Rule:MF_02003]
-[[Category: Car, Z]]
+__TOC__
-[[Category: Brkic, A]]
+</StructureSection>
-[[Category: Zanki, V]]
+[[Category: Large Structures]]
-[[Category: Jablonska, J]]
+[[Category: Priestia megaterium]]
+[[Category: Ban N]]
+[[Category: Brkic A]]
+[[Category: Car Z]]
+[[Category: Gruic-Sovulj I]]
+[[Category: Jablonska J]]
+[[Category: Leibundgut M]]
+[[Category: Petrovic Perokovic V]]
+[[Category: Zanki V]]