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==Structure of cobalamin-dependent methionine synthase (MetH) in a resting state== | |||
<StructureSection load='8g3h' size='340' side='right'caption='[[8g3h]], [[Resolution|resolution]] 3.60Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8g3h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermus_filiformis Thermus filiformis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8G3H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8G3H FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.6Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=B12:COBALAMIN'>B12</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8g3h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8g3h OCA], [https://pdbe.org/8g3h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8g3h RCSB], [https://www.ebi.ac.uk/pdbsum/8g3h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8g3h ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/A0A0A2XCD7_THEFI A0A0A2XCD7_THEFI] Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.[ARBA:ARBA00025552][PIRNR:PIRNR000381] | |||
==See Also== | |||
*[[Methionine synthase 3D structures|Methionine synthase 3D structures]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Thermus filiformis]] | |||
[[Category: Ando N]] | |||
[[Category: Watkins MB]] | |||
Latest revision as of 09:47, 19 June 2024
Structure of cobalamin-dependent methionine synthase (MetH) in a resting stateStructure of cobalamin-dependent methionine synthase (MetH) in a resting state
Structural highlights
FunctionA0A0A2XCD7_THEFI Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.[ARBA:ARBA00025552][PIRNR:PIRNR000381] See Also |
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