8cb6: Difference between revisions

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OCA

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-'''Unreleased structure'''
-The entry 8cb6 is ON HOLD
+==Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in covalent complex with TAMRA tagged 1,6-Epi-cylcophellitol aziridine activity based probe==
+<StructureSection load='8cb6' size='340' side='right'caption='[[8cb6]], [[Resolution|resolution]] 1.90&Aring;' scene=''>
-Authors: Sulzenbacher, G., Roig-Zamboni, V., Overkleeft, H., Artola, M.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8cb6]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8CB6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8CB6 FirstGlance]. <br>
-Description: Crystal structure of human lysosomal acid-alpha-glucosidase, GAA, in covalent complex with TAMRA tagged 1,6-Epi-cylcophellitol aziridine activity based probe
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.9&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=CSO:S-HYDROXYCYSTEINE'>CSO</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene>, <scene name='pdbligand=PGE:TRIETHYLENE+GLYCOL'>PGE</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=U54:(1S,2R,3R,4R,5R)-5-[8-[4-(4-azanylbutyl)-1,2,3-triazol-1-yl]octylamino]-4-(hydroxymethyl)cyclohexane-1,2,3-triol'>U54</scene></td></tr>
-[[Category: Roig-Zamboni, V]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8cb6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8cb6 OCA], [https://pdbe.org/8cb6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8cb6 RCSB], [https://www.ebi.ac.uk/pdbsum/8cb6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8cb6 ProSAT]</span></td></tr>
-[[Category: Artola, M]]
+</table>
-[[Category: Overkleeft, H]]
+== Disease ==
-[[Category: Sulzenbacher, G]]
+[https://www.uniprot.org/uniprot/LYAG_HUMAN LYAG_HUMAN] Glycogen storage disease due to acid maltase deficiency, infantile onset;Glycogen storage disease due to acid maltase deficiency, juvenile onset;Glycogen storage disease due to acid maltase deficiency, adult onset. The disease is caused by mutations affecting the gene represented in this entry.
+== Function ==
+[https://www.uniprot.org/uniprot/LYAG_HUMAN LYAG_HUMAN] Essential for the degradation of glygogen to glucose in lysosomes.
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Artola M]]
+[[Category: Overkleeft H]]
+[[Category: Roig-Zamboni V]]
+[[Category: Sulzenbacher G]]