7ft8: Difference between revisions

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New page: '''Unreleased structure''' The entry 7ft8 is ON HOLD Authors: Bradshaw, W.J., Katis, V.L., Bountra, C., von Delft, F., Brennan, P.E. Description: SDCBP PanDDA analysis group deposition...
 
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'''Unreleased structure'''


The entry 7ft8 is ON HOLD
==SDCBP PanDDA analysis group deposition -- The PDZ domans of SDCBP in complex with NCL-00024671==
<StructureSection load='7ft8' size='340' side='right'caption='[[7ft8]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[7ft8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7FT8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7FT8 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALA:ALANINE'>ALA</scene>, <scene name='pdbligand=DGL:D-GLUTAMIC+ACID'>DGL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=GLY:GLYCINE'>GLY</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene>, <scene name='pdbligand=UU1:2-(4-bromo-1H-pyrazol-1-yl)ethan-1-ol'>UU1</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7ft8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7ft8 OCA], [https://pdbe.org/7ft8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7ft8 RCSB], [https://www.ebi.ac.uk/pdbsum/7ft8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7ft8 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/SDCB1_HUMAN SDCB1_HUMAN] Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway.<ref>PMID:10230395</ref> <ref>PMID:11179419</ref> <ref>PMID:11498591</ref>


Authors: Bradshaw, W.J., Katis, V.L., Bountra, C., von Delft, F., Brennan, P.E.
==See Also==
 
*[[3D structures of syntenin|3D structures of syntenin]]
Description: SDCBP PanDDA analysis group deposition --The PDZ domans of SDCBP in complex with NCL-00024671
== References ==
[[Category: Unreleased Structures]]
<references/>
[[Category: Katis, V.L]]
__TOC__
[[Category: Von Delft, F]]
</StructureSection>
[[Category: Bountra, C]]
[[Category: Homo sapiens]]
[[Category: Brennan, P.E]]
[[Category: Large Structures]]
[[Category: Bradshaw, W.J]]
[[Category: Bountra C]]
[[Category: Bradshaw WJ]]
[[Category: Brennan PE]]
[[Category: Katis VL]]
[[Category: Von Delft F]]

Latest revision as of 13:33, 22 May 2024

SDCBP PanDDA analysis group deposition -- The PDZ domans of SDCBP in complex with NCL-00024671SDCBP PanDDA analysis group deposition -- The PDZ domans of SDCBP in complex with NCL-00024671

Structural highlights

7ft8 is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.4Å
Ligands:, , , , ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

SDCB1_HUMAN Seems to function as an adapter protein. In adherens junctions may function to couple syndecans to cytoskeletal proteins or signaling components. Seems to couple transcription factor SOX4 to the IL-5 receptor (IL5RA). May also play a role in vesicular trafficking. Seems to be required for the targeting of TGFA to the cell surface in the early secretory pathway.[1] [2] [3]

See Also

References

  1. ↑ Fernandez-Larrea J, Merlos-Suarez A, Urena JM, Baselga J, Arribas J. A role for a PDZ protein in the early secretory pathway for the targeting of proTGF-alpha to the cell surface. Mol Cell. 1999 Apr;3(4):423-33. PMID:10230395
  2. ↑ Zimmermann P, Tomatis D, Rosas M, Grootjans J, Leenaerts I, Degeest G, Reekmans G, Coomans C, David G. Characterization of syntenin, a syndecan-binding PDZ protein, as a component of cell adhesion sites and microfilaments. Mol Biol Cell. 2001 Feb;12(2):339-50. PMID:11179419
  3. ↑ Geijsen N, Uings IJ, Pals C, Armstrong J, McKinnon M, Raaijmakers JA, Lammers JW, Koenderman L, Coffer PJ. Cytokine-specific transcriptional regulation through an IL-5Ralpha interacting protein. Science. 2001 Aug 10;293(5532):1136-8. PMID:11498591 doi:http://dx.doi.org/10.1126/science.1059157

7ft8, resolution 2.40Å

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