Gluconeogenesis: Difference between revisions

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Alexander Berchansky

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 <StructureSection load='2y3i' size='350' side='right' scene='' caption='Human phosphoglycerate kinase complex with phosphoglyceric acid, ADP (stick model) AlF4-, Cl- and Mg+2 ions (green) (PDB code [[2y3i]])'>
-'''Under development!'''
+Gluconeogenesis ([https://en.wikipedia.org/wiki/Gluconeogenesis]) is a metabolic pathway that results in the generation of glucose from certain non-carbohydrate carbon substrates. In humans the main gluconeogenic precursors are lactate, <scene name='92/925544/Cv/1'>glycerol</scene> (which is a part of the triglyceride molecule), alanine and glutamine. Other glucogenic amino acids and all [[Citric Acid Cycle]] intermediates (through conversion to oxaloacetate) can also function as substrates for gluconeogenesis. See also [[Cori cycle]] and [[Glyoxylate cycle]].
-Gluconeogenesis ([https://en.wikipedia.org/wiki/Gluconeogenesis]) is a metabolic pathway that results in the generation of glucose from certain non-carbohydrate carbon substrates. In humans the main gluconeogenic precursors are lactate, <scene name='92/925544/Cv/1'>glycerol</scene> (which is a part of the triglyceride molecule), alanine and glutamine. Other glucogenic amino acids and all [[Citric Acid Cycle]] intermediates (through conversion to oxaloacetate) can also function as substrates for gluconeogenesis.
 <scene name='39/392339/Cv1/10'>Lactate</scene> is transported back to the liver where it is converted into <scene name='39/392339/Cv1/11'>pyruvate</scene> by the [[Cori cycle]] using the enzyme [[lactate dehydrogenase]]. <scene name='Lactate_Dehydrogenase/Cv/4'>Interconversion of pyruvate and lactate acid</scene>. Pyruvate, the first designated substrate of the gluconeogenic pathway, can then be used to generate glucose.