|
|
| (One intermediate revision by one other user not shown) |
| Line 3: |
Line 3: |
| '''Cytochrome bc1''' (Cbc1) functions as the central pump which transfers protons across the cell membrane. The protons are used to power the rotation of ATP synthase. Cbc1 binds ubiquinol which carries hydrogen atoms. Cbc1 separates the protons and the electrons. The protons are released in the inner side of the membrane for use by ATP synthase and the electrons are transferred to cytochrome c or to the outer side of the membrane. Plants use '''cytochrome b6f''' in the same manner binding plastoquinol as a hydrogen carrier. Stigmatellin inhibits the Cbc1 electron transfer by binding to its quinone oxidation site. Antimycin inhibits Cbc1 by binding to its quinone reduction site.<ref>PMID:14977419</ref> | | '''Cytochrome bc1''' (Cbc1) functions as the central pump which transfers protons across the cell membrane. The protons are used to power the rotation of ATP synthase. Cbc1 binds ubiquinol which carries hydrogen atoms. Cbc1 separates the protons and the electrons. The protons are released in the inner side of the membrane for use by ATP synthase and the electrons are transferred to cytochrome c or to the outer side of the membrane. Plants use '''cytochrome b6f''' in the same manner binding plastoquinol as a hydrogen carrier. Stigmatellin inhibits the Cbc1 electron transfer by binding to its quinone oxidation site. Antimycin inhibits Cbc1 by binding to its quinone reduction site.<ref>PMID:14977419</ref> |
|
| |
|
| More details in [[Complex_III_of_Electron_Transport_Chain]]. | | More details in [[Complex III of Electron Transport Chain]]. |
|
| |
|
| == Structural highlights == | | == Structural highlights == |
| Line 10: |
Line 10: |
| </StructureSection> | | </StructureSection> |
| ==3D structures of cytochrome bc1== | | ==3D structures of cytochrome bc1== |
|
| |
| [[Cytochrome bc1 3D structures]] | | [[Cytochrome bc1 3D structures]] |
|
| |
| Updated on {{REVISIONDAY2}}-{{MONTHNAME|{{REVISIONMONTH}}}}-{{REVISIONYEAR}}
| |
|
| |
| [[1bgy]], [[1be3]], [[1l0n]], [[1ntm]] - bCb + bCc1 + RISP – bovine <BR />
| |
| [[1qcr]] - bCb + bCc1 + RISP – Cα model<BR />
| |
| [[1sqp]], [[2fyu]], [[1l0l]], [[1ntk]], [[1pp9]], [[1ppj]], [[1sqb]], [[2a06]], [[1sqv]], [[1sqx]], [[1sqq]] - bCb + bCc1 + RISP + inhibitor<BR />
| |
| [[4d6u]] - bCb + bCc1 + RISP + antimalarial pyridone<BR />
| |
| [[1ntz]] - bCb + bCc1 + RISP + ubiquinone<BR />
| |
| [[1nu1]], [[6xvf]] - bCb + bCc1 + RISP + quinolone derivative<BR />
| |
| [[6nhg]] - bCb in respiratory complex <BR />
| |
| [[6fo2]] - bCb in respiratory complex – Cryo EM<BR />
| |
| [[6haw]], [[6zfs]], [[6zft]], [[6zfu]] - bCb in respiratory complex + antimalarial inhibitor<BR />
| |
| [[6fo0]], [[6fo6]] - bCb in respiratory complex + antimalarial inhibitor – Cryo EM<BR />
| |
| [[7o37]], [[7o3c]], [[7o3e]], [[7o3h]] - Cb in CICIII2 complex – mouse - Cryo EM<BR />
| |
| [[3cxh]], [[3h1h]], [[1bcc]], [[3h1h]] - cCb + cCc1 + RISP - chicken<BR />
| |
| [[3cwb]], [[3h1i]], [[3h1j]], [[3h1k]], [[3h1l]], [[3l70]], [[3l71]], [[3l72]], [[3l73]], [[3l74]], [[3l75]], [[3tgu]], [[3bcc]], [[2bcc]], [[3h1i]] - cCb + cCc1 + RISP + inhibitor<BR />
| |
| [[7jrg]], [[7jrp]] - Cb in III2 complex – bean - Cryo EM <BR />
| |
| [[2ibz]], [[1kyo]], [[1kb9]], [[1p84]] - yCb + yCc1 + RISP + inhibitor - yeast<BR />
| |
| [[3cx5]] - yCb + yCc1 + RISP <BR />
| |
| [[1ezv]] - yCb + yCc1 + RISP + antibody<BR />
| |
| [[6giq]], [[6hu9]], [[6t0b]], [[6t15]], [[6ymx]] - yCb in respiratory complex – Cryo EM <BR />
| |
| [[2fyn]] - RsCb (mutant) + Cc1 + RISP – ''Rhodobacter sphaeroides<''BR />
| |
| [[2qjk]] - RsCb (mutant) + RsCc1 + RISP + inhibitor<BR />
| |
| [[2qjp]] - RsCb + RsCc1 + RISP + inhibitor<BR />
| |
| [[2qjy]] - RsCb (mutant) + RsCc1 + RISP (mutant) + inhibitor<BR />
| |
| [[1zrt]] - Cb + Cc1 + RISP – ''Rhodobacter capsulatus''<BR />
| |
| [[2yiu]] - Cb + Cc1 + RISP – ''Paracoccus denitrificans''<BR />
| |
| [[7rja]], [[7rjb]], [[7rjc]], [[7rjd]], [[7rje]] - Cb in III2 complex – ''Candida albicans'' - Cryo EM <BR />
| |
| [[7e1v]] - MtCb in respiratory complex – ''Mycobacterium tuberculosis'' - Cryo EM <BR />
| |
| [[7e1w]], [[7e1x]] - MtCb in respiratory complex + drug - Cryo EM <BR />
| |
| [[7rh5]], [[7rh6]], [[7rh7]] - Cb in CIII2CIV2 complex – ''Mycobacterium smegmatis'' - Cryo EM <BR />
| |
| [[7q21]], [[7qhm]], [[7qho]] - Cb in CIII2CIV2 complex –'' Corynebacterium glutamicum'' - Cryo EM <BR />
| |
|
| |
|
| |
|
| == References == | | == References == |