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The | ==The cryo-EM structure of GSNOR with NYY001== | ||
<StructureSection load='8gv3' size='340' side='right'caption='[[8gv3]], [[Resolution|resolution]] 3.05Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8gv3]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8GV3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8GV3 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.05Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=WKZ:(4P)-4-{2-[4-(1H-imidazol-1-yl)phenyl]-5-[3-oxo-3-(2-oxo-1,3-thiazolidin-3-yl)propyl]-1H-pyrrol-1-yl}-3-methylbenzamide'>WKZ</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8gv3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8gv3 OCA], [https://pdbe.org/8gv3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8gv3 RCSB], [https://www.ebi.ac.uk/pdbsum/8gv3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8gv3 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ADHX_HUMAN ADHX_HUMAN] Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Cao Y]] | |||
[[Category: Ji Y]] | |||
[[Category: Xia Y]] | |||
[[Category: Xie L]] | |||
[[Category: Yao D]] | |||
[[Category: Zhang Q]] | |||
[[Category: Zhao S]] | |||
Latest revision as of 17:42, 20 September 2023
The cryo-EM structure of GSNOR with NYY001The cryo-EM structure of GSNOR with NYY001
Structural highlights
FunctionADHX_HUMAN Class-III ADH is remarkably ineffective in oxidizing ethanol, but it readily catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. |
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