8ep7: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[8ep7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis_str._'Ames_Ancestor' Bacillus anthracis str. 'Ames Ancestor']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EP7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EP7 FirstGlance]. <br> | <table><tr><td colspan='2'>[[8ep7]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_anthracis_str._'Ames_Ancestor' Bacillus anthracis str. 'Ames Ancestor']. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8EP7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8EP7 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ep7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ep7 OCA], [https://pdbe.org/8ep7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ep7 RCSB], [https://www.ebi.ac.uk/pdbsum/8ep7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ep7 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8ep7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8ep7 OCA], [https://pdbe.org/8ep7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8ep7 RCSB], [https://www.ebi.ac.uk/pdbsum/8ep7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8ep7 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/ILVC2_BACAN ILVC2_BACAN] Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.[HAMAP-Rule:MF_00435] | [https://www.uniprot.org/uniprot/ILVC2_BACAN ILVC2_BACAN] Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.[HAMAP-Rule:MF_00435] | ||
==See Also== | |||
*[[Ketol-acid reductoisomerase 3D structures|Ketol-acid reductoisomerase 3D structures]] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
Latest revision as of 13:22, 25 October 2023
Crystal Structure of the Ketol-acid Reductoisomerase from Bacillus anthracis in complex with NADPCrystal Structure of the Ketol-acid Reductoisomerase from Bacillus anthracis in complex with NADP
Structural highlights
FunctionILVC2_BACAN Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.[HAMAP-Rule:MF_00435] See Also |
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