4e0h: Difference between revisions
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== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4e0h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E0H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E0H FirstGlance]. <br> | <table><tr><td colspan='2'>[[4e0h]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4E0H OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4E0H FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=FAD:FLAVIN-ADENINE+DINUCLEOTIDE'>FAD</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e0h OCA], [https://pdbe.org/4e0h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e0h RCSB], [https://www.ebi.ac.uk/pdbsum/4e0h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e0h ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4e0h FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4e0h OCA], [https://pdbe.org/4e0h PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4e0h RCSB], [https://www.ebi.ac.uk/pdbsum/4e0h PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4e0h ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/ERV1_YEAST ERV1_YEAST] FAD-dependent sulfhydryl oxidase that catalyzes disulfide bond formation. Required for the import and folding of small cysteine-containing proteins in the mitochondrial intermembrane space (IMS). Forms a redox cycle with MIA40 that involves a disulfide relay system. Important for maintaining the cysteine residues in MIA40 in an oxidized state. Reduced ERV1 is reoxidized by cytochrome c. Required for the maturation of cytoplasmic, but not of mitochondrial Fe/S proteins.[PROSITE-ProRule:PRU00654]<ref>PMID:10899311</ref> <ref>PMID:11493598</ref> <ref>PMID:12654008</ref> <ref>PMID:15989955</ref> <ref>PMID:16181637</ref> <ref>PMID:16185707</ref> | |||
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== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||