8b0v: Difference between revisions
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New page: '''Unreleased structure''' The entry 8b0v is ON HOLD Authors: Description: Category: Unreleased Structures |
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==Crystal structure of C-terminal domain of Pseudomonas aeruginosa LexA G91D mutant== | |||
<StructureSection load='8b0v' size='340' side='right'caption='[[8b0v]], [[Resolution|resolution]] 1.70Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8b0v]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Pseudomonas_aeruginosa Pseudomonas aeruginosa]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8B0V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8B0V FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | |||
[[Category: | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=MES:2-(N-MORPHOLINO)-ETHANESULFONIC+ACID'>MES</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8b0v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8b0v OCA], [https://pdbe.org/8b0v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8b0v RCSB], [https://www.ebi.ac.uk/pdbsum/8b0v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8b0v ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/LEXA_PSEAE LEXA_PSEAE] Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Large Structures]] | |||
[[Category: Pseudomonas aeruginosa]] | |||
[[Category: Cendron L]] | |||
[[Category: Chinellato M]] | |||
[[Category: De Felice S]] | |||
[[Category: Maso L]] | |||
[[Category: Vascon F]] | |||
Latest revision as of 13:07, 27 March 2024
Crystal structure of C-terminal domain of Pseudomonas aeruginosa LexA G91D mutantCrystal structure of C-terminal domain of Pseudomonas aeruginosa LexA G91D mutant
Structural highlights
FunctionLEXA_PSEAE Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. |
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