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==Cryo-EM structure of the 20S Alpha 3 Deletion proteasome core particle== | ==Cryo-EM structure of the 20S Alpha 3 Deletion proteasome core particle== | ||
<StructureSection load='7tej' size='340' side='right'caption='[[7tej]]' scene=''> | <StructureSection load='7tej' size='340' side='right'caption='[[7tej]], [[Resolution|resolution]] 2.74Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TEJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TEJ FirstGlance]. <br> | <table><tr><td colspan='2'>[[7tej]] is a 22 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7TEJ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7TEJ FirstGlance]. <br> | ||
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tej OCA], [https://pdbe.org/7tej PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tej RCSB], [https://www.ebi.ac.uk/pdbsum/7tej PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tej ProSAT]</span></td></tr> | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.74Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7tej FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7tej OCA], [https://pdbe.org/7tej PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7tej RCSB], [https://www.ebi.ac.uk/pdbsum/7tej PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7tej ProSAT]</span></td></tr> | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/PSB2_YEAST PSB2_YEAST] The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. | |||
==See Also== | |||
*[[Proteasome 3D structures|Proteasome 3D structures]] | |||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Saccharomyces cerevisiae S288C]] | |||
[[Category: Hanna J]] | [[Category: Hanna J]] | ||
[[Category: Rawson S]] | [[Category: Rawson S]] | ||
[[Category: Schnell HM]] | [[Category: Schnell HM]] | ||
[[Category: Walsh Jr RM]] | [[Category: Walsh Jr RM]] | ||
Latest revision as of 16:08, 1 March 2024
Cryo-EM structure of the 20S Alpha 3 Deletion proteasome core particleCryo-EM structure of the 20S Alpha 3 Deletion proteasome core particle
Structural highlights
FunctionPSB2_YEAST The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. See Also |
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