Phytase: Difference between revisions
No edit summary |
Michal Harel (talk | contribs) No edit summary |
||
| (3 intermediate revisions by one other user not shown) | |||
| Line 1: | Line 1: | ||
<StructureSection load='3mmj' size='340' side='right' caption='Phytase in complex with inositol hexakisphosphate, phosphate, | <StructureSection load='3mmj' size='340' side='right' caption='Phytase in complex with inositol hexakisphosphate, phosphate, acetate, glycerol and Cl- ion (PDB code [[3mmj]])' scene='91/917455/Cv/1'> | ||
== Function == | == Function == | ||
'''Phytase''' (PHYT) catalyzes the hydrolysis of phytate (myo-inositol hexakisphosphate) to myo-inositol and inorganic phosphate <ref>PMID:9025298</ref>. PHYT are a subclass of the histidine acid phosphatase<ref>PMID:9025298</ref>. Phytate is the main phosphorus storage system in plant seeds. Phytate is indigestible by monogastric animals and humans<ref>PMID:32271147</ref>. | '''Phytase''' or '''purple acid phosphatase''' or '''acidphosphatase''' (PHYT) catalyzes the hydrolysis of phytate (myo-inositol hexakisphosphate) to myo-inositol and inorganic phosphate <ref>PMID:9025298</ref>. PHYT are a subclass of the histidine acid phosphatase<ref>PMID:9025298</ref>. Phytate is the main phosphorus storage system in plant seeds. Phytate is indigestible by monogastric animals and humans<ref>PMID:32271147</ref>. | ||
== Relevance == | == Relevance == | ||
| Line 11: | Line 11: | ||
== Structural highlights == | == Structural highlights == | ||
The 3D structure of the complex between phytase and myo-inositol hexakisphosphate shows the extensive contacts of the phosphoryl groups of the substrate binding in the highly basic binding pocket<ref>PMID:22139834</ref>. | The 3D structure of <scene name='91/917455/Cv/6'>the complex between phytase and myo-inositol hexakisphosphate</scene> shows the extensive contacts of the phosphoryl groups of the substrate binding in the <scene name='91/917455/Cv/8'>highly basic binding pocket</scene><ref>PMID:22139834</ref>. Positively charged residues are colored in magenta; water molecules are shown as red spheres. | ||
==3D structures of phytase== | ==3D structures of phytase== | ||