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[[Image:1hmh.jpg|left|200px]]


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==THREE-DIMENSIONAL STRUCTURE OF A HAMMERHEAD RIBOZYME==
The line below this paragraph, containing "STRUCTURE_1hmh", creates the "Structure Box" on the page.
<StructureSection load='1hmh' size='340' side='right'caption='[[1hmh]], [[Resolution|resolution]] 2.60&Aring;' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1hmh]] is a 6 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HMH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HMH FirstGlance]. <br>
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</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.6&#8491;</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hmh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hmh OCA], [https://pdbe.org/1hmh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hmh RCSB], [https://www.ebi.ac.uk/pdbsum/1hmh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hmh ProSAT]</span></td></tr>
{{STRUCTURE_1hmh|  PDB=1hmh |  SCENE= }}
</table>


'''THREE-DIMENSIONAL STRUCTURE OF A HAMMERHEAD RIBOZYME'''
==See Also==
 
*[[Ribozyme 3D structures|Ribozyme 3D structures]]
 
__TOC__
==Overview==
</StructureSection>
The hammerhead ribozyme is a small catalytic RNA motif made up of three base-paired stems and a core of highly conserved, non-complementary nucleotides essential for catalysis. The X-ray crystallographic structure of a hammerhead RNA-DNA ribozyme-inhibitor complex at 2.6 A resolution reveals that the base-paired stems are A-form helices and that the core has two structural domains. The first domain is formed by the sequence 5'-CUGA following stem I and is a sharp turn identical to the uridine turn of transfer RNA, whereas the second is a non-Watson-Crick three-base-pair duplex with a divalent-ion binding site. The phosphodiester backbone of the DNA inhibitor strand is splayed out at the phosphate 5' to the cleavage site. The structure indicates that the ribozyme may destabilize a substrate strand in order to facilitate twisting of the substrate to allow cleavage of the scissile bond.
[[Category: Large Structures]]
 
[[Category: Flaherty KM]]
==About this Structure==
[[Category: McKay DB]]
Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HMH OCA].
[[Category: Pley HW]]
 
==Reference==
Three-dimensional structure of a hammerhead ribozyme., Pley HW, Flaherty KM, McKay DB, Nature. 1994 Nov 3;372(6501):68-74. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/7969422 7969422]
[[Category: Flaherty, K M.]]
[[Category: McKay, D B.]]
[[Category: Pley, H W.]]
[[Category: Dna-rna hammerhead ribozyme]]
[[Category: Loop]]
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Fri May  2 19:00:55 2008''

Latest revision as of 10:28, 7 February 2024

THREE-DIMENSIONAL STRUCTURE OF A HAMMERHEAD RIBOZYMETHREE-DIMENSIONAL STRUCTURE OF A HAMMERHEAD RIBOZYME

Structural highlights

1hmh is a 6 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 2.6Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

See Also

1hmh, resolution 2.60Å

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