8a61: Difference between revisions

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-'''Unreleased structure'''
-The entry 8a61 is ON HOLD  until sometime in the future
+==S. cerevisiae apo phosphorylated APC/C==
+<StructureSection load='8a61' size='340' side='right'caption='[[8a61]], [[Resolution|resolution]] 5.40&Aring;' scene=''>
-Authors: Barford, D., Vazquez, E.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[8a61]] is a 14 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8A61 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8A61 FirstGlance]. <br>
-Description: S. cerevisiae apo phosphorylated APC/C
+</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8a61 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8a61 OCA], [https://pdbe.org/8a61 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8a61 RCSB], [https://www.ebi.ac.uk/pdbsum/8a61 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8a61 ProSAT]</span></td></tr>
-[[Category: Unreleased Structures]]
+</table>
-[[Category: Barford, D]]
+== Function ==
-[[Category: Vazquez, E]]
+[[https://www.uniprot.org/uniprot/CDC27_YEAST CDC27_YEAST]] Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C is thought to confer substrate specificity and, in the presence of ubiquitin-conjugating E2 enzymes, it catalyzes the formation of protein-ubiquitin conjugates that are subsequently degraded by the 26S proteasome. In early mitosis, the APC/C is activated by CDC20 and targets securin PDS1, the B-type cyclin CLB5, and other anaphase inhibitory proteins for proteolysis, thereby triggering the separation of sister chromatids at the metaphase-to-anaphase transition. In late mitosis and in G1, degradation of CLB5 allows activation of the APC/C by CDH1, which is needed to destroy CDC20 and the B-type cyclin CLB2 to allow exit from mitosis and creating the low CDK state necessary for cytokinesis and for reforming prereplicative complexes in G1 prior to another round of replication.<ref>PMID:10871279</ref> <ref>PMID:15060174</ref> <ref>PMID:7925276</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
+[[Category: Saccharomyces cerevisiae]]
+[[Category: Barford D]]
+[[Category: Fernandez-Vazquez E]]
+[[Category: Yang J]]
+[[Category: Zhang Z]]