3q9g: Difference between revisions
No edit summary |
No edit summary |
||
| Line 4: | Line 4: | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3q9g]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q9G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q9G FirstGlance]. <br> | <table><tr><td colspan='2'>[[3q9g]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3Q9G OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3Q9G FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.05Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=4BF:4-BROMO-L-PHENYLALANINE'>4BF</scene>, <scene name='pdbligand=ACY:ACETIC+ACID'>ACY</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HAO:{[3-(HYDRAZINOCARBONYL)-4-METHOXYPHENYL]AMINO}(OXO)ACETIC+ACID'>HAO</scene>, <scene name='pdbligand=ORN:L-ORNITHINE'>ORN</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q9g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q9g OCA], [https://pdbe.org/3q9g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q9g RCSB], [https://www.ebi.ac.uk/pdbsum/3q9g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q9g ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3q9g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3q9g OCA], [https://pdbe.org/3q9g PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3q9g RCSB], [https://www.ebi.ac.uk/pdbsum/3q9g PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3q9g ProSAT]</span></td></tr> | ||
</table> | </table> | ||
| Line 26: | Line 25: | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Cheng | [[Category: Cheng P]] | ||
[[Category: Eisenberg | [[Category: Eisenberg D]] | ||
[[Category: Liu | [[Category: Liu C]] | ||
[[Category: Nowick | [[Category: Nowick JS]] | ||
[[Category: Sawaya | [[Category: Sawaya MR]] | ||
[[Category: Zheng | [[Category: Zheng J]] | ||
Latest revision as of 12:03, 15 November 2023
VQIVY segment from Alzheimer's tau displayed on 42-membered macrocycle scaffoldVQIVY segment from Alzheimer's tau displayed on 42-membered macrocycle scaffold
Structural highlights
Publication Abstract from PubMedProtein amyloid oligomers have been strongly linked to amyloid diseases and can be intermediates to amyloid fibers. beta-Sheets have been identified in amyloid oligomers. However, because of their transient and highly polymorphic properties, the details of their self-association remain elusive. Here we explore oligomer structure using a model system: macrocyclic peptides. Key amyloidogenic sequences from Abeta and tau were incorporated into macrocycles, thereby restraining them to beta-strands, but limiting the growth of the oligomers so they may crystallize and cannot fibrillate. We determined the atomic structures for four such oligomers, and all four reveal tetrameric interfaces in which beta-sheet dimers pair together by highly complementary, dry interfaces, analogous to steric zippers found in fibers, suggesting a common structure for amyloid oligomers and fibers. In amyloid fibers, the axes of the paired sheets are either parallel or antiparallel, whereas the oligomeric interfaces display a variety of sheet-to-sheet pairing angles, offering a structural explanation for the heterogeneity of amyloid oligomers. Characteristics of Amyloid-Related Oligomers Revealed by Crystal Structures of Macrocyclic beta-Sheet Mimics.,Liu C, Sawaya MR, Cheng PN, Zheng J, Nowick JS, Eisenberg D J Am Chem Soc. 2011 May 4;133(17):6736-44. Epub 2011 Apr 7. PMID:21473620[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. See AlsoReferences
|
| ||||||||||||||||||