7xv8: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-'''Unreleased structure'''
-The entry 7xv8 is ON HOLD  until Paper Publication
+==Crystal structure of the Human TR4 DNA-Binding Domain Homodimer Bound to DR1 Response Element==
+<StructureSection load='7xv8' size='340' side='right'caption='[[7xv8]], [[Resolution|resolution]] 3.20&Aring;' scene=''>
-Authors: Liu, Y., Chen, Z.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7xv8]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/DNA_molecule DNA molecule] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7XV8 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7XV8 FirstGlance]. <br>
-Description: Crystal structure of the Human TR4 DNA-Binding Domain Homodimer Bound to DR1 Response Element
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.199&#8491;</td></tr>
-[[Category: Unreleased Structures]]
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
-[[Category: Chen, Z]]
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7xv8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7xv8 OCA], [https://pdbe.org/7xv8 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7xv8 RCSB], [https://www.ebi.ac.uk/pdbsum/7xv8 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7xv8 ProSAT]</span></td></tr>
-[[Category: Liu, Y]]
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/NR2C2_HUMAN NR2C2_HUMAN] Orphan nuclear receptor that can act as a repressor or activator of transcription. An important repressor of nuclear recptor signaling pathways such as retinoic acid receptor, retinoid X, vitamin D3 receptor, thyroid hormone receptor and estrogen receptor pathways. May regulate gene expression during the late phase of spermatogenesis. Together with NR2C1, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription including that of GATA1. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Plays a fundamental role in early embryonic development and embryonic stem cells. Required for normal spermatogenesis and cerebellum development. Appears to be important for neurodevelopmentally regulated behavior (By similarity). Activates transcriptional activity of LHCG. Antagonist of PPARA-mediated transactivation.<ref>PMID:7779113</ref> <ref>PMID:9556573</ref> <ref>PMID:10347174</ref> <ref>PMID:10644740</ref> <ref>PMID:17974920</ref>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: DNA molecule]]
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Chen Z]]
+[[Category: Liu Y]]