3pr0: Difference between revisions
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<StructureSection load='3pr0' size='340' side='right'caption='[[3pr0]], [[Resolution|resolution]] 2.20Å' scene=''> | <StructureSection load='3pr0' size='340' side='right'caption='[[3pr0]], [[Resolution|resolution]] 2.20Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3pr0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3pr0]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3PR0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3PR0 FirstGlance]. <br> | ||
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=JG2:7-PHENYL-1-[5-(PYRIDIN-2-YL)-1,3,4-OXADIAZOL-2-YL]HEPTANE-1,1-DIOL'>JG2</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.2Å</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=JG2:7-PHENYL-1-[5-(PYRIDIN-2-YL)-1,3,4-OXADIAZOL-2-YL]HEPTANE-1,1-DIOL'>JG2</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pr0 OCA], [https://pdbe.org/3pr0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pr0 RCSB], [https://www.ebi.ac.uk/pdbsum/3pr0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pr0 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3pr0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3pr0 OCA], [https://pdbe.org/3pr0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3pr0 RCSB], [https://www.ebi.ac.uk/pdbsum/3pr0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3pr0 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/FAAH1_RAT FAAH1_RAT] Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity). | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Rattus norvegicus]] | ||
[[Category: | [[Category: Boger DL]] | ||
[[Category: | [[Category: Han GW]] | ||
[[Category: | [[Category: Mileni M]] | ||
[[Category: | [[Category: Stevens RC]] | ||