3oiq: Difference between revisions

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<StructureSection load='3oiq' size='340' side='right'caption='[[3oiq]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
<StructureSection load='3oiq' size='340' side='right'caption='[[3oiq]], [[Resolution|resolution]] 2.40&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[3oiq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Atcc_18824 Atcc 18824]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OIQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OIQ FirstGlance]. <br>
<table><tr><td colspan='2'>[[3oiq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3OIQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3OIQ FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[3oip|3oip]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.4&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">CDC13, YDL220C ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=4932 ATCC 18824])</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oiq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oiq OCA], [https://pdbe.org/3oiq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oiq RCSB], [https://www.ebi.ac.uk/pdbsum/3oiq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oiq ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3oiq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3oiq OCA], [https://pdbe.org/3oiq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3oiq RCSB], [https://www.ebi.ac.uk/pdbsum/3oiq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3oiq ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/CDC13_YEAST CDC13_YEAST]] Single-stranded telomeric DNA-binding protein that regulates telomere replication. Has a role in both positive and negative regulation. Promotes [TG(1-3)] strand lengthening via interaction with EST1. Promotes [C(1-3)A] strand re-synthesis by DNA polymerase alpha via interaction with POL1. Negatively regulates telomere elongation of the G strand via binding with STN1 thereby inhibiting telomerase activity.<ref>PMID:11230149</ref> <ref>PMID:11390652</ref> <ref>PMID:10898792</ref> [[https://www.uniprot.org/uniprot/DPOA_YEAST DPOA_YEAST]] Catalytic component of DNA polymerase alpha, which in complex with DNA primase (DNA polymerase alpha:primase) consitutes a replicative polymerase. POL1 has a role in promoting telomere replication during interaction with CDC13.<ref>PMID:10898792</ref> 
[https://www.uniprot.org/uniprot/CDC13_YEAST CDC13_YEAST] Single-stranded telomeric DNA-binding protein that regulates telomere replication. Has a role in both positive and negative regulation. Promotes [TG(1-3)] strand lengthening via interaction with EST1. Promotes [C(1-3)A] strand re-synthesis by DNA polymerase alpha via interaction with POL1. Negatively regulates telomere elongation of the G strand via binding with STN1 thereby inhibiting telomerase activity.<ref>PMID:11230149</ref> <ref>PMID:11390652</ref> <ref>PMID:10898792</ref>  
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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</div>
</div>
<div class="pdbe-citations 3oiq" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 3oiq" style="background-color:#fffaf0;"></div>
==See Also==
*[[DNA polymerase 3D structures|DNA polymerase 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Atcc 18824]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: DeZwaan, D C]]
[[Category: Saccharomyces cerevisiae]]
[[Category: Freeman, B C]]
[[Category: DeZwaan DC]]
[[Category: Lei, M]]
[[Category: Freeman BC]]
[[Category: Lin, J J]]
[[Category: Lei M]]
[[Category: Lin, Y C]]
[[Category: Lin JJ]]
[[Category: Lue, N F]]
[[Category: Lin YC]]
[[Category: Mao, N]]
[[Category: Lue NF]]
[[Category: Sun, J]]
[[Category: Mao N]]
[[Category: Wan, K]]
[[Category: Sun J]]
[[Category: Yang, Y]]
[[Category: Wan K]]
[[Category: Yu, T Y]]
[[Category: Yang Y]]
[[Category: Dimer]]
[[Category: Yu TY]]
[[Category: Dimeric complex]]
[[Category: Ob fold]]
[[Category: Protein binding]]

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