7awk: Difference between revisions

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<StructureSection load='7awk' size='340' side='right'caption='[[7awk]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
<StructureSection load='7awk' size='340' side='right'caption='[[7awk]], [[Resolution|resolution]] 1.91&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[7awk]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AWK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7AWK FirstGlance]. <br>
<table><tr><td colspan='2'>Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7AWK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7AWK FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7awk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7awk OCA], [https://pdbe.org/7awk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7awk RCSB], [https://www.ebi.ac.uk/pdbsum/7awk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7awk ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.91&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7awk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7awk OCA], [https://pdbe.org/7awk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7awk RCSB], [https://www.ebi.ac.uk/pdbsum/7awk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7awk ProSAT]</span></td></tr>
</table>
</table>
== Function ==
[[https://www.uniprot.org/uniprot/HIGB1_MYCTU HIGB1_MYCTU]] Toxic component of an atypical, type II toxin-antitoxin chaperone (TAC) system. Upon expression in M.smegmatis inhibits colony formation and cell growth (PubMed:20011113, PubMed:23927792). Ectopic expression in wild-type M.tuberculosis has no effect on cell growth; ectopic expression in a triple higB1-higA1-Rv1957 (delta TAC) disruption mutant causes growth arrest, killing a considerable proportion of the cells. Increased ectopic expression leads to decreased levels of IdeR- and Zur-regulated genes as well as cleavage within the mRNA region of tmRNA (transfer-mRNA), strongly suggesting it is an endoribonuclease; also degrades E.coli and M-smegmatis tmRNA (PubMed:23927792). Its toxic effect is neutralized by coexpression with antitoxin HigA. Neutralization of HigB1 toxin in E.coli or M.marinum also requires SecB-like chaperone Rv1957, making this the first toxin-antitoxin chaperone (TAC) system (PubMed:21536872).<ref>PMID:19016878</ref> <ref>PMID:20011113</ref> <ref>PMID:21536872</ref> <ref>PMID:23927792</ref> 
== References ==
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Bigot, D J]]
[[Category: Bigot DJ]]
[[Category: Guillet, V]]
[[Category: Guillet V]]
[[Category: Mourey, L]]
[[Category: Mourey L]]
[[Category: Mycobacterium tuberculosis]]
[[Category: Rnase]]
[[Category: Toxin]]
[[Category: Toxin-antitoxin-chaperone]]

Latest revision as of 09:11, 19 June 2024

Crystal structure of the HigB1 toxin mutant K95A from Mycobacterium tuberculosis (Rv1955)Crystal structure of the HigB1 toxin mutant K95A from Mycobacterium tuberculosis (Rv1955)

Structural highlights

Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.91Å
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

7awk, resolution 1.91Å

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA
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