7zsm: Difference between revisions

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-'''Unreleased structure'''
-The entry 7zsm is ON HOLD
+==human purine nucleoside phosphorylase in complex with JS-375==
+<StructureSection load='7zsm' size='340' side='right'caption='[[7zsm]], [[Resolution|resolution]] 2.65&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[7zsm]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7ZSM OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7ZSM FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.65&#8491;</td></tr>
+<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=JU9:[(~{E})-2-[4-methoxy-2-[(4-oxidanylidene-3,5-dihydropyrrolo[3,2-d]pyrimidin-7-yl)sulfanyl]phenyl]ethenyl]phosphonic+acid'>JU9</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7zsm FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7zsm OCA], [https://pdbe.org/7zsm PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7zsm RCSB], [https://www.ebi.ac.uk/pdbsum/7zsm PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7zsm ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN] Defects in PNP are the cause of purine nucleoside phosphorylase deficiency (PNPD) [MIM:[https://omim.org/entry/613179 613179]. It leads to a severe T-cell immunodeficiency with neurologic disorder in children.<ref>PMID:3029074</ref> <ref>PMID:1384322</ref> <ref>PMID:8931706</ref>
+== Function ==
+[https://www.uniprot.org/uniprot/PNPH_HUMAN PNPH_HUMAN] The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.<ref>PMID:2104852</ref>
-Authors: Djukic, S., Pachl, P., Rezacova, P.
+==See Also==
+*[[Purine nucleoside phosphorylase 3D structures|Purine nucleoside phosphorylase 3D structures]]
-Description: human purine nucleoside phosphorylase in complex with JS-375
+== References ==
-[[Category: Unreleased Structures]]
+<references/>
-[[Category: Rezacova, P]]
+__TOC__
-[[Category: Pachl, P]]
+</StructureSection>
-[[Category: Djukic, S]]
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Djukic S]]
+[[Category: Pachl P]]
+[[Category: Rezacova P]]