Methionine synthase: Difference between revisions

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Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

Kia Yang, Karsten Theis, Michael O'Shaughnessy, Anna Postnikova, Michal Harel

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-'''Methionine synthase''' (MS; EC: 2.1.1.13) is the enzyme in [[one-carbon metabolism]] linking the folate cycle to the methionine cycle. MS catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate (5- me THF) to homocysteine, resulting in the formation of methionine and tetrahydrofolate (THF). Methionine is an essential amino acid required by our bodies for healthy cell and tissue growth. It is essential as it is not naturally derived in our bodies. As it is used as a methyl donor in the form of S-adenosylmethionine, the resulting homocysteine is recyled to form methionine again.
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+'''Methionine synthase''' (MS; EC: 2.1.1.13) or '''5-methyltetrahydrofolate S-homocysteine methyltransferase''' is the enzyme in [[one-carbon metabolism]] linking the folate cycle to the methionine cycle. MS catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate (5- me THF) to homocysteine, resulting in the formation of methionine and tetrahydrofolate (THF). Methionine is an essential amino acid required by our bodies for healthy cell and tissue growth. It is essential as it is not naturally derived in our bodies. As it is used as a methyl donor in the form of S-adenosylmethionine, the resulting homocysteine is recyled to form methionine again.
 [[Image:Overall.jpg]]
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 == Structural highlights ==
+==Methionine synthase 3D structures==
+[[Methionine synthase 3D structures]]
 <StructureSection load='' size='400' side='right' scene='90/907471/Superposition_1/3'>
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 The full structure of MS has yet to be determined.
-Shown here is the <scene name='90/907471/Superposition/7'>theoretical prediction</scene> of the structure by the alphafold algorithm, with experimental structures of the N-terminal 2 domains as well as of the C-terminal 2 domins superposed.
+Shown here is the <scene name='90/907471/Superposition/8'>theoretical prediction</scene> of the structure by the [[alphafold]] algorithm, with experimental structures of the N-terminal 2 domains as well as of the C-terminal 2 domins superposed.
 <jmol>