3ii7: Difference between revisions
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<StructureSection load='3ii7' size='340' side='right'caption='[[3ii7]], [[Resolution|resolution]] 1.63Å' scene=''> | <StructureSection load='3ii7' size='340' side='right'caption='[[3ii7]], [[Resolution|resolution]] 1.63Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[3ii7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[3ii7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3II7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=3II7 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.63Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ii7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ii7 OCA], [https://pdbe.org/3ii7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ii7 RCSB], [https://www.ebi.ac.uk/pdbsum/3ii7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ii7 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=3ii7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3ii7 OCA], [https://pdbe.org/3ii7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=3ii7 RCSB], [https://www.ebi.ac.uk/pdbsum/3ii7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=3ii7 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
[https://www.uniprot.org/uniprot/KLHL7_HUMAN KLHL7_HUMAN] Retinitis pigmentosa. The disease is caused by mutations affecting the gene represented in this entry. | |||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/KLHL7_HUMAN KLHL7_HUMAN] Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex. The BCR(KLHL7) complex acts by mediating ubiquitination and subsequent degradation of substrate proteins. Probably mediates 'Lys-48'-linked ubiquitination.<ref>PMID:21828050</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Arrowsmith | [[Category: Arrowsmith CH]] | ||
[[Category: Bountra | [[Category: Bountra C]] | ||
[[Category: Bullock | [[Category: Bullock A]] | ||
[[Category: Chaikuad | [[Category: Chaikuad A]] | ||
[[Category: Cooper | [[Category: Cooper CDO]] | ||
[[Category: Edwards AM]] | |||
[[Category: Edwards | [[Category: Filippakopoulos P]] | ||
[[Category: Filippakopoulos | [[Category: Knapp S]] | ||
[[Category: Knapp | [[Category: Krojer T]] | ||
[[Category: Krojer | [[Category: Muniz JRC]] | ||
[[Category: Muniz | [[Category: Pike ACW]] | ||
[[Category: Pike | [[Category: Sethi R]] | ||
[[Category: Thangaratnarajah C]] | |||
[[Category: Sethi | [[Category: Ugochukwu E]] | ||
[[Category: Thangaratnarajah | [[Category: Weigelt J]] | ||
[[Category: Ugochukwu | [[Category: Von Delft F]] | ||
[[Category: Weigelt | |||
[[Category: | |||