2wya: Difference between revisions
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<StructureSection load='2wya' size='340' side='right'caption='[[2wya]], [[Resolution|resolution]] 1.70Å' scene=''> | <StructureSection load='2wya' size='340' side='right'caption='[[2wya]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2wya]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2wya]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. This structure supersedes the now removed PDB entry [http://oca.weizmann.ac.il/oca-bin/send-pdb?obs=1&id=2v4w 2v4w]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2WYA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2WYA FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.7Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=HMG:3-HYDROXY-3-METHYLGLUTARYL-COENZYME+A'>HMG</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wya OCA], [https://pdbe.org/2wya PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wya RCSB], [https://www.ebi.ac.uk/pdbsum/2wya PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wya ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2wya FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2wya OCA], [https://pdbe.org/2wya PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2wya RCSB], [https://www.ebi.ac.uk/pdbsum/2wya PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2wya ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | |||
[https://www.uniprot.org/uniprot/HMCS2_HUMAN HMCS2_HUMAN] 3-hydroxy-3-methylglutaryl-CoA synthase deficiency. The disease is caused by variants affecting the gene represented in this entry. | |||
== Function == | |||
[https://www.uniprot.org/uniprot/HMCS2_HUMAN HMCS2_HUMAN] Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate.<ref>PMID:11228257</ref> <ref>PMID:23751782</ref> <ref>PMID:29597274</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Arrowsmith | [[Category: Arrowsmith C]] | ||
[[Category: Bountra | [[Category: Bountra C]] | ||
[[Category: Cooper | [[Category: Cooper C]] | ||
[[Category: Edwards A]] | |||
[[Category: Edwards | [[Category: Murray JW]] | ||
[[Category: Murray | [[Category: Oppermann U]] | ||
[[Category: Oppermann | [[Category: Roos AK]] | ||
[[Category: Roos | [[Category: Savitsky P]] | ||
[[Category: Savitsky | [[Category: Shafqat N]] | ||
[[Category: Shafqat | [[Category: Wikstrom M]] | ||
[[Category: Wikstrom | [[Category: Yue WW]] | ||
[[Category: Yue | [[Category: Von Delft F]] | ||
[[Category: | |||