7uj2: Difference between revisions
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New page: '''Unreleased structure''' The entry 7uj2 is ON HOLD Authors: Description: Category: Unreleased Structures |
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==OspC Type K== | |||
<StructureSection load='7uj2' size='340' side='right'caption='[[7uj2]], [[Resolution|resolution]] 1.50Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[7uj2]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Borreliella_burgdorferi_297 Borreliella burgdorferi 297]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=7UJ2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=7UJ2 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.503Å</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=7uj2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=7uj2 OCA], [https://pdbe.org/7uj2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=7uj2 RCSB], [https://www.ebi.ac.uk/pdbsum/7uj2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=7uj2 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/OSPC2_BORBG OSPC2_BORBG] Major immunodominant protein in mammalian hosts. Required for initial stages of mammalian infection. Inhibits macrophage-mediated phagocytosis of the bacteria. Binds human plasminogen; this probably confers an extracellular protease activity on the bacteria that allows it to traverse tissue. Interaction with tick I.ricinus salivary protein Salp15 protects the bacteria from antibody-mediated killing in vitro and in vivo.[UniProtKB:Q07337] | |||
==See Also== | |||
*[[Outer surface protein|Outer surface protein]] | |||
__TOC__ | |||
[[Category: | </StructureSection> | ||
[[Category: Borreliella burgdorferi 297]] | |||
[[Category: Large Structures]] | |||
[[Category: Mantis N]] | |||
[[Category: Rudolph MJ]] | |||
Latest revision as of 20:16, 18 October 2023
OspC Type KOspC Type K
Structural highlights
FunctionOSPC2_BORBG Major immunodominant protein in mammalian hosts. Required for initial stages of mammalian infection. Inhibits macrophage-mediated phagocytosis of the bacteria. Binds human plasminogen; this probably confers an extracellular protease activity on the bacteria that allows it to traverse tissue. Interaction with tick I.ricinus salivary protein Salp15 protects the bacteria from antibody-mediated killing in vitro and in vivo.[UniProtKB:Q07337] See Also |
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